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EC number: 254-879-2 | CAS number: 40306-75-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Aquatic Toxicity :
Short-term toxicity to Fish :
The lethal concentration (LC50) value of phthalylsulfathiazole in fish (Pimephales promelas) in a 96 hr study on mortality effect was estimated to be 245.685mg/L. The supporting studies also predicted an LC50 value above 100 mg/L
Sr. No |
Endpoint name |
Value |
Units |
Species |
1 |
LC50 | 245.685 | mg/l | Pimephales promelas |
2 | LC50 | 152.0679 | mg/l | Oncorhynchus mykiss |
3 | LC50 | 147.8293 | mg/l | Lepomis macrochirus |
Therefore it can be concluded that the substance is not classified as per CLP criteria.
Short -term toxicity to Aquatic invertebrate :
The LC50 value of 3-acetamido-5-amino-4-hydroxybenzenesulphonic acid in aquatic invertebrate (Daphnia Magna) in a 48 hr study on mortality was estimated to be 718.3787 mg/L. No of studies reviewed for Short term toxicity to aquatic invertebrate and the results have been summarised below:
Sr. No |
Endpoint name |
Value |
Units |
Species |
1 |
LC50 | 718.3787 | mg/l | Daphnia Magna |
2 | EC50 | 120.2614 | mg/l | Daphnia Magna |
3 | LC50 | 107.762 | mg/l | Daphnia Magna |
4 | LC 50 | 284.638 | mg/l | Daphnia Magna |
Based on the above endpoint values of QSAR and supporting studies(ECOSAR) and considering the CLP Criteria for aquatic classification it can be concluded that the substance3-acetamido-5-amino-4-hydroxybenzene sulphonic acid does not exhibit short term toxicity to aquatic invertebrate (Daphnia Magna).Therefore it can be concluded that the substance is not classified.
Toxicity to aquatic algae and cynobacteria :
The effective concentration (EC50) value of 3-acetamido-5-amino-4-hydroxybenzenesulphonic acid in aquatic algae (Pseudokirchneriella subcapitata) in a 72 hr study based upon effect on growth was estimated to be 199.5558 mg/L. The summary of the results are presented below
Sr. No |
Endpoint name |
Value |
Units |
Species |
1 |
EC 50 | 199.5558 | mg/l | Pseudokirchneriella subcapitata |
2 | EC 50 | 179.126 | mg/l | Green algae |
3 | EC 50 | 380.534 | mg/l | Green algae |
Based on the above endpoint value of QSAR and supporting studies(ECOSAR) and considering the CLP Criteria for aquatic classification it can be concluded that the substance3-acetamido-5-amino-4-hydroxybenzene sulphonic acid do not exhibit short term toxicity to aquatic algae (Pseudokirchneriella subcapitata) .Therefore it can be concluded that the substance is not classified as per the CLP criteria.
Toxicity to microorganism :
Toxicity value(IG50 -46 h) of 3-acetamido-5-amino-4-hydroxybenzenesulphonic acid to Tetrahymena pyriformis on the basis of growth inhibition is estimated as 309.9978 mg/L indicating that the substance do not have toxic effect on micro-organism.
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