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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_physical-and-chemical-properties.png)
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 03 March 2011 to 08 March 2011
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted to EU & OECD test guidance in compliance with GLP and reported with a valid GLP certificate.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
Test material
- Details on test material:
- Name: Reactive Blue F08-0170
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- < -2.04
- Remarks on result:
- other: Temp & pH not detailed in report
- Details on results:
- Details in table form: see any other information
Any other information on results incl. tables
Partition coefficients measured for Reactive Blue F08-0170 (Component 1)
Ratio of solvents (n-octanol : water) |
Partition coefficient |
Log Pow |
|
Pow |
Mean |
||
1:1 |
<0.0100 |
<0.0102 |
<-1.99 |
<0.0106 |
|||
<0.0100 |
|||
2:1 |
<0.0115 |
<0.0128 |
<-1.89 |
<0.0179* |
|||
<0.0141 |
|||
1:2 |
<0.0058 |
<0.0058 |
<-2.24 |
<0.0060 |
|||
<0.0056 |
|||
Mean all±95% confidence interval |
|
<0.0096±0.0088 |
<-2.04±0.436 |
SD |
|
0.0035 |
0.176 |
* chromatographic error, did not use for the calculations
Partition coefficients measured for Reactive Blue F08-170 (Component 2)
Ratio of solvents (n-octanol : water) |
Partition coefficient |
Log Pow |
|
Pow |
Mean |
||
1:1 |
<0.0079 |
<0.0080 |
<-2.10 |
<0.0082 |
|||
<0.0079 |
|||
2:1 |
<0.0105 |
<0.0112 |
<-1.95 |
<0.0120 |
|||
<0.0110 |
|||
1:2 |
<0.0053 |
<0.0053 |
<-2.28 |
<0.0054 |
|||
<0.0051 |
|||
Mean all±95% confidence interval |
|
<0.0081±0.0073 |
<-2.11±0.405 |
SD |
|
0.0030 |
0.163 |
Partition coefficients measured for Reactive Blue F08-0170 (Component 3)
Ratio of solvents (n-octanol : water) |
Partition coefficient |
Log Pow |
|
Pow |
Mean |
||
1:1 |
<0.0091 |
<0.0091 |
<-2.04 |
<0.0089 |
|||
<0.0092 |
|||
2:1 |
<0.0122 |
<0.0119 |
<-1.92 |
<0.0118 |
|||
<0.0118 |
|||
1:2 |
<0.0060 |
<0.0059 |
<-2.23 |
<0.0057 |
|||
<0.0059 |
|||
Mean all±95% confidence interval |
|
<0.0090±0.0075 |
<-2.07±0.384 |
SD |
|
0.0030 |
0.155 |
Partition coefficients measured for Reactive Blue F08-0170 (Component 4)
Ratio of solvents (n-octanol : water) |
Partition coefficient |
Log Pow |
|
Pow |
Mean |
||
1:1 |
<0.0035 |
<0.0035 |
<-2.45 |
<0.0036 |
|||
<0.0035 |
|||
2:1 |
<0.0046 |
<0.0047 |
<-2.33 |
<0.0047 |
|||
<0.0047 |
|||
1:2 |
<0.0025 |
<0.0024 |
<-2.62 |
<0.0023 |
|||
<0.0025 |
|||
Mean all±95% confidence interval |
|
<0.0035±0.0028 |
<-2.47±0.356 |
SD |
|
0.0011 |
0.143 |
Applicant's summary and conclusion
- Conclusions:
- In conclusion, the partition coefficient (Pow) of Reactive Blue F08-0170 in n-octanol-water was determined to be < 0.0096 +/- 0.0088 (95% confidence interval) using shake flask method.
Log Pow < -2.04 - Executive summary:
This study has been performed in accordance with the study plan, Directive of the European Communities: Methods for the Determination of Physico-Chemical Properties (A.8), Organisation for Economic Co-operation and Development (OECD), OECD Guidelines for Testing of Chemicals, Guideline No. 107,”Partition Coefficient (n-octanol/water): Shake Flask Method”, adopted July 27, 1995 and the Principles of Good Laboratory Practice (GLP) and reported with a valid GLP certificate.
The purpose of this study was to determine the partition coefficient of Reactive Blue F08-0170. The test item is a reaction mass of 6 components. For this test only 4 of the main components were determined. The two remaining components are contained in a very low concentration, causing no effect on the results of the study.
In conclusion, the partition coefficient (Pow) of Reactive Blue F08-0170 in n-octanol-water was determined to be < 0.0096 ± 0.0088 (95% confidence interval) using shake flask method.
Log Pow: < -2.04
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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