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EC number: 500-295-0 | CAS number: 106233-09-4 1 - 2.5 moles ethoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Oral LD50 (OECD guideline 401), rat > 10000 mg/kg bw
Dermal LD50 (OECD guideline 402), rat > 2000 mg/kg bw
Acute toxicity by inhalation was not tested according to REGULATION (EC) No 1907/2006, Annex VIII, Section 8.5, Column 2.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- The available information comprises adequate, reliable (Klimisch score 2) and consistent studies from a reference substance with similar structure and intrinsic properties. Read-across is justified based on breakdown products and similarities in PC/TOX properties (refer to endpoint discussion for further details). The selected study is thus sufficient to fulfil the standard information requirements set out in Annex VII, 8.5, in accordance with Annex XI, 1.5, of Regulation (EC) No 1907/2006.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- The available information comprises adequate, reliable (Klimisch score 2) and consistent studies from a reference substance with similar structure and intrinsic properties. Read-across is justified based on breakdown products and similarities in PC/TOX properties (refer to endpoint discussion for further details). The selected study is thus sufficient to fulfil the standard information requirements set out in Annex VII, 8.5, in accordance with Annex XI, 1.5, of Regulation (EC) No 1907/2006.
Additional information
Justification for grouping of substances and read-across
There are no data available for the acute toxicity of Alcohols, C16-18, ethoxylated, phosphates (CAS 106233-09-4). In order to fulfil the standard information requirements set out in Annex VIII in accordance with Annex XI, 1.5, of Regulation (EC) No 1907/2006, read-across from structurally related substances was conducted.
In accordance with Article 13 (1) of Regulation (EC) No 1907/2006, "information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI are met.” In particular for human toxicity, information shall be generated whenever possible by means other than vertebrate animal tests, which includes the use of information from structurally related substances (grouping or read-across).
Having regard to the general rules for grouping of substances and read-across approach laid down in Annex XI, 1.5, of Regulation (EC) No 1907/2006, whereby physicochemical, toxicological and ecotoxicological properties may be predicted from data for reference substance(s) by interpolation to other substances on the basis of structural similarity,Alcohols C16-18 (even numbered), ethoxylated (< 2.5 EO)(CAS 68439-49-6) and Alcohols C10-16, ethoxylated (< 2.5 EO)(CAS 68002-97-1) are selected as source substances for assessment of acute toxicity.
Acute toxicity
|
Target substance |
Source substance |
Source substance |
CAS |
106233-09-4 (a) |
68439-49-6 (b) |
68002-97-1 (b) |
Chemical name |
Alcohols, C16-18, ethoxylated, phosphates |
Alcohols C16-18 (even numbered), ethoxylated (< 2.5 EO) |
Alcohols C10-16, ethoxylated (< 2.5 EO) |
MW |
322.42 – 867.27 g/mol |
242.5 – 402.7 g/mol |
158.3 – 346.6 g/mol |
Acute toxicity, oral |
RA:68439-49-6 |
Experimental result:LD50 > 10,000 mg/kg bw |
-- |
Acute toxicity, dermal |
RA:68002-97-1 |
-- |
Experimental result:LD50 > 2000 mg/kg bw |
(a) The substance subject to the REACh Phase-in registration deadline of 31 May 2013 is indicated in bold font. Only for this substance a full set of experimental results and/or read-across is given.
(b) Reference (read-across) substances are indicated in normal font. Lack of data for a given endpoint is indicated by “--“.
The read-across is mainly based on similar precursers/breakdown products of the target and the source substances. The available endpoint information is used to predict the same endpoint forAlcohols, C16-18, ethoxylated, phosphates(CAS 106233-09-4).
A detailed analogue approach justification is provided in the technical dossier (see IUCLID Section 13).
Discussion
An acute oral toxicitystudy conducted withAlcohols C16-18 (even numbered), ethoxylated (< 2.5 EO) (CAS 68439-49-6)was performed according to OECD Guideline 401 with 5 Wistar rats per sex (Mürmann, 1986). The animals received a single dose of 10,000 mg/kg bw test substance via gavage. No mortality occurred. The only clinical sign of toxicity observed was piloerection. No effects on body weight and upon necropsy were observed. The LD50 is greater than 10,000 mg/kg bw.
An acute dermal toxicity study with Alcohols C10-16, ethoxylated (< 2.5 EO) (CAS 68002-97-1) was conducted similar to OECD Guideline 402 (Thompson, 1982). The test substance was applied at a dose of 2000 mg/kg bw to the abraded skin of New Zealand White rabbits for 24 h under occlusive conditions. No mortality occurred and thus a LD50 > 2000 mg/kg bw was determined. No data on clinical signs, body weight or gross pathology were given.
In general, alcohol ethoxylates are of low oral, dermal, and inhalation toxicity (HERA, 2009). The length of the alky chain had no meaningful influence on the toxicity. The degree of ethoxylation of the alcohol ethoxylates had some influence on the acute oral toxicity, with compounds with ethoxylate chains between 5 and 14 being more toxic than those with less than 4 or more than 15. In the available studies (n = 6) with a degree of ethoxylation of less than 4, which would correspond to the breakdown products ofAlcohols, C16-18, ethoxylated, phosphates, the LD50 were all greater than 6000 mg/kg bw (HERA, 2009).
Furthermore, sulphates and phosphates of ethoxylated alcohols are expected to be not acutely toxic by the oral and dermal routes (EPA, 2009). Studies performed withAlcohols, C12-16, ethoxylated (4 EO)phosphate (CAS 39464-66-9) showed an oral LD50 of 6550 mg/kg bw and a dermal LD50 of 5010 mg/kg bw (Younger laboratories, 1992; EPA, 2003). Several data on alcohol ethoxy sulphates are available for the oral and dermal route indicating a low acute toxicity (Younger laboratories, 1992; HERA, 2003).
Conclusion
Based on the available information on breakdown products ofAlcohols, C16-18, ethoxylated, phosphates and the information gained from reports onsulphates and phosphates of ethoxylated alcohols, no acute toxicity is expected forAlcohols, C16-18, ethoxylated, phosphates.
References
Younger Laboratories (1992)Initial Submission: Toxicological Investigation Of: Ethfac - Sample # 251 b with Cover Letter dated 081492. US EPA, NTIS/OTS: 0538618.
Justification for selection of acute toxicity – oral endpoint
Only one study available.
Justification for selection of acute toxicity – dermal endpoint
Only one study available.
Justification for classification or non-classification
Based on information from structurally similar substances, the available data on oral and dermal toxicity do not meet the classification criteria according to Regulation (EC) 1272/2008 or Directive 67/548/EEC, and are therefore conclusive but not sufficient for classification.
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