Registration Dossier
Registration Dossier
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EC number: 202-452-6 | CAS number: 95-79-4
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- sub-chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Reference Type:
- secondary source
- Title:
- BUA Stoffbericht 55: Chlortoluidine (3-Chlor-2-methylanilin, 5-Chlor-2-methylanilin, 3-Chlor-4-methylanilin)
- Author:
- BUA Beratergremium für umweltrelevante Altstoffe
- Year:
- 1 990
- Bibliographic source:
- Verlag Chemie Weinheim 1991
Materials and methods
Test guideline
- Guideline:
- other: no data
- Principles of method if other than guideline:
- see BUA Stoffberichte No. 55 for details
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 5-chloro-o-toluidine
- EC Number:
- 202-452-6
- EC Name:
- 5-chloro-o-toluidine
- Cas Number:
- 95-79-4
- Molecular formula:
- C7H8ClN
- IUPAC Name:
- 5-chloro-2-methylaniline
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 4 weeks
- Frequency of treatment:
- no data
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
31.5 mg/kg BW
Basis:
nominal in diet
- Remarks:
- Doses / Concentrations:
68 mg/kg BW
Basis:
nominal in diet
- Remarks:
- Doses / Concentrations:
146.5 mg/kg BW
Basis:
nominal in diet
- Remarks:
- Doses / Concentrations:
315.5 mg/kg BW
Basis:
nominal in diet
- Remarks:
- Doses / Concentrations:
680 mg/kg BW
Basis:
nominal in diet
- No. of animals per sex per dose:
- 5
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Description (incidence and severity):
- No mortallity. 100 % of the animals survived.
- Mortality:
- no mortality observed
- Description (incidence):
- No mortallity. 100 % of the animals survived.
- Body weight and weight changes:
- effects observed, treatment-related
- Description (incidence and severity):
- reduced weight increase rate
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- effects observed, treatment-related
- Description (incidence and severity):
- speckled liver and kidneys even at lowest concentration
- Histopathological findings: non-neoplastic:
- no effects observed
- Histopathological findings: neoplastic:
- no effects observed
Effect levels
- Remarks on result:
- not measured/tested
- Remarks:
- Effect level not specified (migrated information)
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
The study was conducted as a preliminary test to determine the optimal dosage for a chronic toxicity study. Therefore no effect level is available.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
