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Diss Factsheets
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EC number: 233-036-2 | CAS number: 10025-67-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
no data
Effect on fertility: via oral route
- Endpoint conclusion:
- no study available
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
According to REACH Annex XI section 3.2 (b) and (c), testing is omitted, based on the scenarios developed in the CSR. In scenarios describing the substance not being incorporated in an article it could be demonstrated that strictly controlled conditions as set out in Article 18.4. (a)-(f) apply througout the life-cycle of the substance. Furthermore it was demonstrated that the substance is not released from articles based on the use of the substance as a monomer and that exposure to workers, to the general public and to the environment it is negligible under normal or reasonable foreseeable conditions.
As outlined in detail in the IUCLID chapter 7.1. toxicokinetics, S2Cl2 is reported in the literature to undergo rapid hydrolysis in aqueous conditions. A guideline test was performed according OECD TG 111 (Hydrolysis as a Function of pH) to verify fast and quantitative hydrolysis in water. As the hydrolysis was known to occur rapidly, hydrolysis behaviour of the test item in aqueous solutions was investigated in a Tier 1 test at room temperature instead of 50 °C, at different pH (4, 7 and 9). Overall, this guideline study according to the OECD TG 111 (Hydrolysis as a Function of pH) showed that S2Cl2 is rapidly (t 1/2 < 2 minutes) and quantitatively (97.7 - 101.7 %) hydrolysed in water at 23 °C and pH ranging from 4 to 9. The hydrolysis products are HCl and different sulphur containing molecules in varying amounts including sulphite, sulphate, thiosulphate, sulphide and precipitable sulphur.
There is comprehensive information on all hydrolysis products available. Based on the evaluations by OECD, SCOEL, and/or German “Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area” (MAK) mentioned in Chapter 7.1. it can be concluded that local irritation is the toxicologically significant property of the hydrolysis products. This is also consistent with data on S2Cl2 which is labeled with R35 (causes severe burns). No relevant systemic toxicity is observed with any of the hydrolysis compounds (e.g. sodium thiosulfate is of low toxicity and authorised as additive or monomer for plastic materials and articles in contact with foods and the amount of chloride ions taken up is << 1/200 of the daily intake of chloride ions from the diet). Consequently, panels on the hydrolysis products consider only the corrosive properties to be relevant and no systemic toxicity is seen in animal experiments and based on calculations of potential exposure in the occupational setting on the hydrolysis compounds.
Moreover, due to the corrosive properties of disulphur dichloride and its vapours, the adverse effects on the gastrointestinal tract and the respiratory system, and the local effects on skin, would dominate over systemic or reproductive effects.
Reproductive toxicology studies with S2Cl2 are therefore superfluous.
Short description of key information:
Waiving: exposure considerations
Effects on developmental toxicity
Description of key information
Waiving: exposure considerations
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Additional information
According to REACH Annex XI section 3.2 (b) and (c), testing is omitted, based on the scenarios developed in the CSR. In scenarios describing the substance not being incorporated in an article it could be demonstrated that strictly controlled conditions as set out in Article 18.4. (a)-(f) apply througout the life-cycle of the substance. Furthermore it was demonstrated that the substance is not released from articles based on the use of the substance as a monomer and that exposure to workers, to the general public and to the environment it is negligible under normal or reasonable foreseeable conditions.
As outlined in detail in the IUCLID chapter 7.1. toxicokinetics, S2Cl2 is reported in the literature to undergo rapid hydrolysis in aqueous conditions. A guideline test was performed according OECD TG 111 (Hydrolysis as a Function of pH) to verify fast and quantitative hydrolysis in water. As the hydrolysis was known to occur rapidly, hydrolysis behaviour of the test item in aqueous solutions was investigated in a Tier 1 test at room temperature instead of 50 °C, at different pH (4, 7 and 9). Overall, this guideline study according to the OECD TG 111 (Hydrolysis as a Function of pH) showed that S2Cl2 is rapidly (t 1/2 < 2 minutes) and quantitatively (97.7 - 101.7 %) hydrolysed in water at 23 °C and pH ranging from 4 to 9. The hydrolysis products are HCl and different sulphur containing molecules in varying amounts including sulphite, sulphate, thiosulphate, sulphide and precipitable sulphur.
There is comprehensive information on all hydrolysis products available. Based on the evaluations by OECD, SCOEL, and/or German “Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area” (MAK) mentioned in Chapter 7.1. it can be concluded that local irritation is the toxicologically significant property of the hydrolysis products. This is also consistent with data on S2Cl2 which is labeled with R35 (causes severe burns). No relevant systemic toxicity is observed with any of the hydrolysis compounds (e.g. sodium thiosulfate is of low toxicity and authorised as additive or monomer for plastic materials and articles in contact with foods and the amount of chloride ions taken up is << 1/200 of the daily intake of chloride ions from the diet). Consequently, panels on the hydrolysis products consider only the corrosive properties to be relevant and no systemic toxicity is seen in animal experiments and based on calculations of potential exposure in the occupational setting on the hydrolysis compounds.
Moreover, due to the corrosive properties of disulphur dichloride and its vapours, the adverse effects on the gastrointestinal tract and the respiratory system, and the local effects on skin, would dominate over systemic or developmental / teratogenic effects. Developmental toxicity study are therefore superfluous.
Toxicity to reproduction: other studies
Additional information
no data
Justification for classification or non-classification
Conclusive, but not sufficient for classification.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.