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Diss Factsheets
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EC number: 228-391-5 | CAS number: 6258-06-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
- Skin: The test substance did not cause skin irritation in the rabbit skin (ECB-IUCLID, 2000).
- Eye: The test substance did not cause irritation of the eye (ECB-IUCLID, 2000).
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Data on the skin and eye irritating potential of the test substance is only available as secondary source (ECB-IUCLID, 2000, Val. 4):
Skin irritation
In one study, 500 mg of test substance was applied on the ear of rabbits under semiocclusive conditions for 24 hours. The animals were observed for 7 days. No irritation was observed and no further details were given (Bayer 1979). The second study revealed no skin irritating properites of the test substance. No more details were given (Marhold 1972). No definite prediction was possible from the BfR rules for skin irritation in the OECD toolbox, since the substance fulfilled each two criteria for inclusion and exclusion in the category of skin irritants.
Eye irritation
In one study, 50 mg of the test substance per animal was applied and the animals were observed for 7 days. This test revealed no irritating properties. No further data was given (Bayer 1979).
A second study revealed slighty irritating properties of the test substance when applied to rabbits (Marhold 1972). No further details were given. This information
Justification for classification or non-classification
Dangerous Substance Directive (67/548/EEC)
Based on the available data of the test substance, classification for skin and eye irritation under Directive 67/548/EEC is not warranted.
Classification, Labeling, and Packaging Regulation (EC) No. 1272/2008
Based on the available data of the test substance, classification for skin and eye irritation under Regulation (EC) No. 1272/2008 is not warranted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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