Pentadecane, 7-methylene-

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

The original study is classified as reliable with restriction because although the study was not GLP compliant, it was conducted according to FHSLA recommendations. For the purposes of this use it is rated as reliable with restrictions since it is being used for read across purposes.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1967

Report date:

1967

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: Federal Hazardous Substances Labeling Act

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Hexadec-1-ene

EC Number:

211-105-8

EC Name:

Hexadec-1-ene

Cas Number:

629-73-2

IUPAC Name:

hexadec-1-ene

Test animals / tissue source

Species:

rabbit

Strain:

other: albino

Test system

Vehicle:

not specified

Controls:

other: The non-treated eye of each animal was used as a control. A positive control substance was also tested.

Amount / concentration applied:

0.01 ml of the test material was instilled into one eye of six male rabbits.

Details on study design:

SCORING SYSTEM: The Draize scoring system was used.

Results and discussion

In vivo

Results

Irritation parameter:

other: Draize

Basis:

mean

Time point:

other: 24 hour

Score:

0.7

Remarks on result:

other: Not irritating

Irritant / corrosive response data:

Instillation of 1-hexadecene in the eyes produced mild, transient redness of the conjunctival tissue. No effects on the cornea or iris were observed. Based on this test result, the author concluded that 1-hexadecene is not an eye irritant to albino rabbits.

Other effects:

The eye treated with control substance, 5% Ivory solution, showed greater response than any of the test substances.

Applicant's summary and conclusion

Interpretation of results:

not irritating

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

Instillation of 1-hexadecene in the eyes produced mild, transient redness of the conjunctival tissue. No effects on the cornea or iris were observed. Based on this test result, the author concluded that 1-hexadecene is not an eye irritant to albino rabbits.

Executive summary:

In a primary eye irritation study, 0.1 millilitre of 1-hexadecene was instilled into the conjunctival sac of six male albino rabbits. Treated eyes were not washed during exposure. The animals were observed at 24, 48 and 72 hours after exposure. Irritation was scored by the Draize method. In this study, 1-hexadecene is not an eye irritant based on the 24 hour average redness Draize score of 0.7. This result for the substance hexadec-1 -ene can be considered representative of the likely result that would be seen with the isomer 7 -methylenepentadecane.