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Diss Factsheets
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EC number: 938-679-9 | CAS number: 308062-29-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1984-9-13 to 1984-10-18
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Consumer Product Safety Commission Protocol
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Amines, C14-16 (even numbered) -alkyldimethyl, N-oxides
- IUPAC Name:
- Amines, C14-16 (even numbered) -alkyldimethyl, N-oxides
- Details on test material:
- - Name of test material (as cited in study report): Ammonyx MCO (30% active)
- Lot/batch No.: 01-41
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: CD
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River
- Age at study initiation: No data
- Weight at study initiation: 200-300 g
- Fasting period before study: 18 hours
- Housing: raised wire mesh cages
- Diet: Lab Blox ad libitum
- Water: ad libitum
- Acclimation period:
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data
- Humidity (%): No data
- Air changes (per hr): Air conditioned quarters
- Photoperiod (hrs dark / hrs light): No data
Administration / exposure
- Route of administration:
- other: Rigid stomach tube
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Following administration of each dose level the animals were observed for fourteen days for signs of toxicity.
- Doses:
- 0.4 mL per 100g bodyweight equating to 4.0 g/kg boidyweight
0.5 mL per 100 g bodeweight equating to 5.0 g/kg bodyweight
0.7 mL per 100 g bodyweight equating to 7.0 g/kg bodyweight - No. of animals per sex per dose:
- 5 males and 5 females per dose level
- Control animals:
- no
- Details on study design:
- The animals were examined daily and mortality recorded. An autopsy was performed if autolysis had not occurred.
- Statistics:
- The method of Litchfield and Wilcoxon was used to calculate the oral LD50 (see Table 1, attached)
Results and discussion
- Preliminary study:
- No data
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 5 600 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: aqueous solution as manufactured and supplied containing 30 %w/w AO
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 680 mg/kg bw
- Based on:
- act. ingr.
- Mortality:
- See Table 1 (attached)
- Clinical signs:
- other: See Table 1 (attached)
- Gross pathology:
- Autopsy were performed on rats that did not show any signs of autolysis. At autopsy, no macroscopic changes were noted in any of the internal organs.
- Other findings:
- No data
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The LD50 was calculated to be 5.6 g/kg bodyweight based on test material. This result equates to an LD50 of 1680 mg/kg bodweight based on active ingredient.
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