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Diss Factsheets
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EC number: 908-996-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- Apr 1968
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Study design similar to OECD Guideline with some deviations; summary report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 968
- Report date:
- 1968
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- dilutions tested
- GLP compliance:
- no
- Remarks:
- performed before GLP
Test material
- Reference substance name:
- Reinigerkomponente M - spezial
- IUPAC Name:
- Reinigerkomponente M - spezial
- Reference substance name:
- Reinigerkomponente M - normal
- IUPAC Name:
- Reinigerkomponente M - normal
- Test material form:
- other: liquid
- Details on test material:
- no data
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: Yellow-silver strain
- Details on test animals or tissues and environmental conditions:
- TEST ANIMAL
- Housing: individually
- Diet (e.g. ad libitum): Standard Altromin K (Altrogge, Lage/Lippe, Germany), ad libitum
- Water (e.g. ad libitum): tap water, ad libitum
Test system
- Vehicle:
- physiological saline
- Controls:
- not required
- Amount / concentration applied:
- 0.1 mL of 1:10 or 1:100 dilution
- Duration of treatment / exposure:
- The eyes were not washed after application.
- Observation period (in vivo):
- 1 hour post application
3 hour post application
7 hour post application
24 hours post application
48 hours post application
72 hours post application - Number of animals or in vitro replicates:
- 5
- Details on study design:
- After treatment the eyes were not washed out.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Remarks:
- only qualitiative description of the effects in the eye available, non guideline study
- Basis:
- mean
- Time point:
- 24/48/72 h
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- probability of severe irritation
- Irritation parameter:
- iris score
- Remarks:
- only qualitiative description of the effects in the eye available, non guideline study
- Basis:
- mean
- Time point:
- 24/48/72 h
- Max. score:
- 2
- Reversibility:
- not specified
- Remarks on result:
- probability of severe irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Max. score:
- 3
- Reversibility:
- not specified
- Remarks on result:
- probability of severe irritation
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- not determinable
- Irritant / corrosive response data:
- - 1:10 dilution:
eye slightly reddened, moderate opacity and swelling of the conjunctivae
- 1:100 dilution:
eye slightly reddened; effects reversible within 1h - Other effects:
- no further data
Any other information on results incl. tables
Observed effects:
- 1:10 dilution:
eye slightly reddened, moderate opacity and swelling of the conjunctivae
- 1:100 dilution:
eye slightly reddened; effects reversible within 1h
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- The application of a 1:10 dilution of the test substance to the eyes of 5 rabbits lead to moderate opacity, reddening and swelling of the conjunctivae.
Therefore it is concluded that the undiluted reaction mass of Methyl dihydrogen phosphate and Orthophosphoric acid and Dimethyl hydrogen phosphate has to be classified as irritant to the eyes (R41 - Risk of serious damage to the eyes; H318 - Causes serious eye damage) according to the criteria laid down in the EU Dangerous Substances Directive (67/548/EEC) and in the EU Classification Labelling and Packaging Regulation (1272/2008/EC). - Executive summary:
A 1:10 and 1:100 dilution of reaction mass of Methyl dihydrogen phosphateand Orthophosphoric acid and Dimethyl hydrogen phosphate were tested for its eye irritant properties in 5 rabbits.The study was performed similar to OECD Guideline 405.
The application of a 1:10 dilution of the test substance to the eyes of 3 rabbits lead to moderate opacity, slight reddening and swelling of the conjunctivae.
Therefore it is concluded that the undiluted reaction mass of Methyl dihydrogen phosphate and Orthophosphoric acid and Dimethyl hydrogen phosphate has to be classified as irritant to the eyes (R41 - Risk of serious damage to the eyes; H318 - Causes serious eye damage) according to the criteria laid down in the EU Dangerous Substances Directive (67/548/EEC) and in the EU Classification Labelling and Packaging Regulation (1272/2008/EC).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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