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Diss Factsheets
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EC number: 938-708-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
The following remarks on the toxicokinetics of Desmodur RC (TDI Trimer) are based on physico-chemical properties of the compound and on toxicological data. Experimental toxicokinetic studies were not performed.
Desmodur RC is a white organic solid with a very low vapour pressure under normal ambient conditions (0.0011 Pa at 20°C), therefore inhalation exposure to the vapour is expected to be negligible. Acute inhalation of a liquid aerosol (dust) of Desmodur RC (25% in ethyl acetate) inhalable to rats revealed no signs of systemic toxicity at the maximum attainable concentration of 1839 mg/m3 air (Pauluhn, 2011). Even subacute (4-week) inhalation of Desmodur RC (25% in ethyl acetate) liquid aerosol to rats revealed no signs of systemic toxicity (Pauluhn, 2012). Due to the lack of systemic toxicity there is no proof of systemic availability after inhalation exposure.
At ambient temperature Desmodur RC undergoes a complete hydrolysis reaction in demineralized water within 24 hours and remains as hydrolysis product in form of an undissolved solid residue (Neuland, 2012). Due to hydrolytic instability of Desmodur RC in aqueous solutions neither water solubility nor log Pow value were determinable. Under physiological conditions it is expected that Desmodur RC decomposes in the GI tract mainly into oligomeric and polymeric ureas. Therefore intestinal absorption of Desmodur RC subsequent to oral ingestion may be limited. This assumption is confirmed by the data on acute oral toxicity in rats (LD50 ≥ 5000 mg/kg bw). In this study a dose of 2000 mg/kg bw was tolerated without mortalities, clinical signs, effects on weight gain or gross pathological findings (Gillissen, 2010).
An acute skin irritation study on rabbits revealed no systemic intolerance reactions after application of 0.5 g Desmodur RC moistened with corn oil (Gmelin, 2010). In this study a slight dermal irritation was seen. On the other hand, Desmodur RC proved as a moderate skin sensitizer in a local lymph node assay (LLNA) in mice (Vohr, 2011), therefore at least some dermal bioavailability after dermal contact is expected.
Based on the results of three in vitro genotoxicity tests (negative with and without metabolicactivation in an Ames test (Sutter and Köppe, 2011), in a HGPRT test (Hall, 2011) as well as in a chromosome aberration test (Nebelung, 2011) it is concluded that DNA-reactive metabolites of Desmodur RC will most probably not be generated in mammals in the course of hepatic biotransformation.
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