Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 221-453-2 | CAS number: 3101-60-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2011
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to the O.E.C.D. test guideline 301D with GLP compliance.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- p-tert-butylphenyl 1-(2,3-epoxy)propyl ether
- EC Number:
- 221-453-2
- EC Name:
- p-tert-butylphenyl 1-(2,3-epoxy)propyl ether
- Cas Number:
- 3101-60-8
- Molecular formula:
- C13H18O2
- IUPAC Name:
- 2-[(4-tert-butylphenoxy)methyl]oxirane
- Reference substance name:
- p-tert-butylphenyl-1-(2,3)-epoxypropyl ether
- IUPAC Name:
- p-tert-butylphenyl-1-(2,3)-epoxypropyl ether
- Reference substance name:
- Oxirane, 2-((4-(1,1-dimethylethyl)phenoxy)methyl)-
- IUPAC Name:
- Oxirane, 2-((4-(1,1-dimethylethyl)phenoxy)methyl)-
- Test material form:
- other: Liquid at room temperature.
- Details on test material:
- As per IUCLID5 Sections 1.1. 1.2. and 4.1.
Constituent 1
Constituent 2
Constituent 3
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- A sample of activated sludge (domestic) was acquired from the Brazos River Valley Sewer Authority
- Duration of test (contact time):
- ca. 28 d
Initial test substance concentration
- Initial conc.:
- ca. 5 mg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- A mineral salts medium was prepared in deionized water and aerated for approximately 19 hours. Minerasalts media was used as a blank, and homogenized for approximately 30 minutes. The test substance (1.5 mg) was applied to aluminum foil and placed in each replicate, resulting in a dose rate of approximately 5 mg/L. The bottles were then filled to a total volume of 300 mL with the prepared mineral salts media. For the Toxicity Reference Solutions 1.5 mg of the test substance was applied to aluminum foil and placed in each replicate. The bottles were then filled to a total volume of 300 mL with the prepared reference solution.
Ten labeled Biologic Oxygen Demand (BOD) bottles were prepared for the blank, 5 mg/L test substance and reference solutions (up to 5 sampling periods). Only six bottles were prepared for the toxicity reference solution. The blank and reference solutions were added to the respective bottles by siphoning from the lower quarter (not from the bottom) of the prepared solution containers. The Day 0 samples were examined for dissolved oxygen and the remaining bottles were stored in the dark and incubated at 22-23 C. Two BOD bottles for each solution were removed at each sampling interval of 0, 7, 14, 21 and 28 days.
Reference substance
- Reference substance:
- aniline
- Remarks:
- 2.0 mg/L
Results and discussion
% Degradation
- Parameter:
- % degradation (O2 consumption)
- Value:
- ca. 1.1
- Sampling time:
- 28 d
- Remarks on result:
- other: Maximum % biodegradation was observed at 28 days of contact.
- Details on results:
- The % biodegradation of the test substance (5.0 mg/L)
________________________________________________________________
Sampling Days 7 14 21 28
% degradation 0.4 0.0 1.0 1.1
BOD5 / COD results
- Results with reference substance:
- The Reference substance 2.0 mg/L distilled aniline reached a maximum % biodegradation of 87.2% at 21 days of contact.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- The test substance is not readily biodegradable under the conditions of the study.
- Executive summary:
The test substance, p-tert-butylphenyl-1-(2,3)-epoxypropyl ether was accessed for potential ready biodegradability in an O.E.C.D. test guideline 301D Closed-Bottle study. The percent Biodegradation of the test substance reached 1.1% at 28 days of sludge contact. Therefore, the test substance is not readily biodegradable under the conditions of the study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.