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EC number: 220-877-5 | CAS number: 2923-16-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
LD50 oral > 2000 mg/kg
LD50 dermal > 1000 mg/kg
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 26 nov 1998 to 03 nov 2000
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study not GLP, but following the OECD guideline.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- not specified
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Nossan S.r.l, Italy
- Age at study initiation:
- Weight at study initiation: males: between 244 and 245 g; females: between 154 and 163 g
- Fasting period before study: an overnight
- Diet (e.g. ad libitum): available 4 hours after dosing
- Water (e.g. ad libitum):
IN-LIFE DATES: From 07 march 2000 to 28 march 2000
No more data available - Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Remarks:
- 0.5%
- Doses:
- 500 and 2000 mg/k bw
- No. of animals per sex per dose:
- 3 females at 500 mg/kg
3 males at 2000 mg/kg - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: animals were observed for clinical signs immediately upon dosing, approximately 1, 2, 4 hours after dosing and daily thereafter for a total of 14 days.
Animals were weighted on allocation to the study, prior to dosing (day 1) and on days 8 and 15.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, gross pathology - Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occured during the study
- Clinical signs:
- other: 500 mg/kg: piloerection observed following dosing. Recovery within 2 days. 2000 mg/kg: piloerection an hunched posture observed following dosing. Recovery within 6 days.
- Gross pathology:
- No abnormalities observed.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Potassium trifluoroacetate is not classified according to the CLP 1272/2008
- Executive summary:
In a study (RTC, 2000), Sprague-Dawley rats received Potassium trifluoroacetate at doses of 500 and 2000 mg/kg in vehicle carboxymethylcellulose (CMC). The animals were observed for 14 days. No mortality was observed. Clinical signs: piloerection at 500 mg.kg (recovery within 2 days); piloerection and hunched posture at 2000 mg/kg with recovery within 6 days. The LD50 was higher than 2000 mg/kg.
In these conditions, Potassium trifluoroacetate is not harmful by ingestion, according to CLP 1272/2008/EC criteria.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- The study is not GLP but is following the OECD guideline.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 22 nov 2011 to 25 jan 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- 2010-12-16
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: CHARLES RIVER (EUROPE) LABORATORIES INC.
- Age at study initiation: young adults
- Weight at study initiation: Between 207g and 269g
- Fasting period before study: none
- Housing: individual caging , Type II. polypropylene/polycarbonate (37*22*18 cm)
- Diet (e.g. ad libitum): ssniff® SM R/M-Z+H "Autoclavable complete feed for rats and mice – breeding and maintenance"
- Water (e.g. ad libitum): tap water from the municipal supply
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 3 °C
- Humidity (%): 30 - 70 %
- Air changes (per hr): 15-20 air exchanges/hour
- Photoperiod (hrs dark / hrs light): 12 hours daily, from 6.00 a.m. to 6.00 p.m.
IN-LIFE DATES: From: 2011-11-30 To: 2011-12-14 - Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Shaved back
- % coverage: 10%
- Type of wrap if used: Sterile gauze pads kept in contact with the skin by a patch with adhesive hypoallergenic plaster. The entire trunk of the animal was wrapped with semi occlusive plastic wrap.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Water
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 5480 mg/kg bw (2000 mg/kg bw of active ingredients)
- Constant volume or concentration used: yes - Duration of exposure:
- 24 hours
- Doses:
- 5480 mg/kg bw (2000 mg/kg bw of active ingredients)
- No. of animals per sex per dose:
- 5 animals per sex and per dose
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
- Clinical signs: 1 and 5 hours after application of the test item and once each day thereafter
- Weighing: Day 0 (before test item administration) and on Days 7 and 14
- Necropsy of survivors performed: yes
- Other examinations performed:
- clinical signs: skin and fur, eyes and mucous membranes, the respiratory, circulatory, autonomic and central nervous system, somatomotor
activity and behaviour pattern. Particular attention was directed to observation of tremors, convulsions, salivation, diarrhea, lethargy, sleep
and coma. - Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- act. ingr.
- Mortality:
- No mortality occurred after a 24-hour dermal exposure
- Clinical signs:
- other: No clinical signs were observed after the treatment with the test item or during the 14 day observation period.
- Gross pathology:
- There was no evidence of any observations at necropsy.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute dermal median lethal dose (LD50) of the test item Reaction mass of TFSK/TFAK was found to be higher than 2000 mg/kg bw (active ingredients) in male and female CRL:(WI)Wistar rats. It is consequently considered as not classified.
- Executive summary:
An acute dermal toxicity study was performed with test item Reaction mass of TFSK/TFAK in CRL:(WI)Wistar rats, in compliance with OECD Guideline No.: 402, and under GLP conditions.
A limit test was carried out at 2000 mg/kg (active ingredients) body weight (bw) in both sexes (5 rats/sex). The test item was applied as supplied as a single dermal 24-hour exposure followed by a 14‑day observation period.
Clinical observations were performed on all animals at 1and 5 hours after dosing and daily for 14 days thereafter. Body weight was measured prior to dosing on Day 0 and on Days 7 and 14. Rats were euthanized and a gross macroscopic examination performed at the end of the 2-week observation period (Day 14).
No mortality occurred during the study. Neither local dermal signs nor clinical signs were observed after the treatment with the test item or during the 14-day observation period. Body weight was normal and necropsy displayed no evidence of any observations at a dose level of 2000 mg/kg bw (active ingredients).
The acute dermal median lethal dose (LD50) of the test item Reaction mass of TFSK/TFAK was found to be higher than 2000 mg/kg bw (active ingredients) in male and female CRL:(WI)Wistar rats. It is consequently considered as not classified.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- The study is GLP and is following the OECD guideline.
Additional information
Oral:
In a study (RTC, 2000), Sprague-Dawley rats received Potassium trifluoroacetate at doses of 500 and 2000 mg/kg in vehicle carboxymethylcellulose (CMC). The animals were observed for 14 days. Clinical signs: piloerection at 500 mg/kg (recovery within 2 days); piloerection and hunched posture at 2000 mg/kg with recovery within 6 days. No mortality was observed. The LD50 was higher than 2000 mg/kg. In these conditions, Potassium trifluoroacetate is not harmful by ingestion according to the CLP 1272/2008/EC criteria.
Dermal:
An acute dermal toxicity study was performed with test item Reaction mass of TFSK/TFAK in CRL:(WI)Wistar rats, in compliance with OECD Guideline No.: 402, and under GLP conditions.
A limit test was carried out at 2000 mg/kg (active ingredients) body weight (bw) in both sexes (5 rats/sex). The test item was applied as supplied as a single dermal 24-hour exposure followed by a 14‑day observation period. Clinical observations were performed on all animals at 1and 5 hours after dosing and daily for 14 days thereafter. Body weight was measured prior to dosing on Day 0 and on Days 7 and 14. Rats were euthanized and a gross macroscopic examination performed at the end of the 2-week observation period (Day 14).
No mortality occurred during the study. Neither local dermal signs nor clinical signs were observed after the treatment with the test item or during the 14-day observation period. Body weight was normal and necropsy displayed no evidence of any observations at a dose level of 2000 mg/kg bw (active ingredients).
The acute dermal median lethal dose (LD50) of the test item Reaction mass of TFSK/TFAK was found to be higher than 2000 mg/kg bw (active ingredients) in male and female CRL:(WI)Wistar rats.
In this study, about 50 % (49.3 %) of the active ingredients is TFAK, the remaining being TFSK. Therefore, actual TFAK LD50 > 1000 mg/kg bw. However, considering that no clinical signs were observed in this study, dermal absorption is expected to be lower than gastrointestinal absorption and because no death was observed in the TFAK oral acute toxicity study, we expect that TFAK LD50 is well over 2000 mg/kg.
TFAK is consequently considered as not classified for acute dermal toxicity.
Inhalation:
No study was available. As there were data on oral and dermal route, data on inhalation route is not required, because it is not the main route of exposure. Considering the very low vapor pressure of TFAK and the absence of toxicity obsrved in dermal and oral acute toxicity studies. No toxicity is expected by the inhalation route.
Justification for classification or non-classification
Based on results observed by oral and dermal route, no classification is required for potassium trifluoroacetate according to the CLP 1272/2008 regulation criteria.
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