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EC number: 216-378-7 | CAS number: 1569-69-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- between 01 February 2010 and 25 February 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was carried out in accordance with internationally valid GLP principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.42 (Skin Sensitisation: Local Lymph Node Assay)
- GLP compliance:
- yes (incl. QA statement)
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- Cyclohexanethiol
- EC Number:
- 216-378-7
- EC Name:
- Cyclohexanethiol
- Cas Number:
- 1569-69-3
- Molecular formula:
- C6H12S
- IUPAC Name:
- cyclohexanethiol
- Reference substance name:
- CYCLOHEXYL MERCAPTAN
- IUPAC Name:
- CYCLOHEXYL MERCAPTAN
- Test material form:
- other: liquid
- Details on test material:
- purity: 99.85%
Description: clear colourless liquid
Batch number: 2009-06-1550
Date received 02 July 2009
Expiry date not supplied
Storage conditions room temperature in the dark
Constituent 1
Constituent 2
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- other: CBAlCa (CBAlCaOlaHsd)
- Sex:
- female
- Details on test animals and environmental conditions:
- On receipt the animals were randomly allocated to cages.
The animals were nulliparous and non-pregnant.
After an acclimatisation period of at least five days the animals were selected at random and given a number unique within the study by indelible ink-marking on the tail and a number written on a cage card.
At the start of the study the animals were: in the weight range of 15 to 23 g,
eight to twelve weeks old.
The animals were individually housed in suspended solid-floor polypropylene cages furnished with softwood woodflakes.
Free access to mains tap water and food was allowed throughout the study.
The temperature and relative humidity were controlled to remain within target ranges of 19 to 25°C and 30 to 70%, respectively.
The rate of air exchange was approximately fifteen changes per hour.
The lighting was controlled by a time switch to give twelve hours continuous light (06.00 to 18.00) and twelve hours darkness.
The animals were provided with environmental enrichment items which were considered not to contain any contaminant of a level that might have affected the purpose or integrity of the study.
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- other: topical application to the dorsal surface of the ear
- Vehicle:
- other: the test material was used undiluted and freshly prepared as a solution in acetone/olive oil 4:1.
- Concentration / amount:
- Screening test: 100% and 50 %
Main test:25% , 50%
Challenge
- Concentration / amount:
- Screening test: 100% and 50 %
Main test:25% , 50%
- No. of animals per dose:
- 5
- Details on study design:
- Groups of five mice were treated with the undiluted test material or the test material at concentrations of 50% or 25% v/v in acetone/olive oil 4:1. The preliminary screening test suggested that the test material would not produce systemic toxicity or excessive local irritation at the highest suitable concentration. The mice were treated by daily application of 25 ~I of the appropriate concentration of the test material to the dorsal surface of each ear for three consecutive days (Days 1, 2, 3). The test material formulation was administered using an automatic micropipette and spread over the dorsal surface of the ear using the tip of the pipette.
A further group of five mice received the vehicle alone in the same manner.
Results and discussion
Any other information on results incl. tables
Main Test:
Estimation of the Proliferative Response of Lymph Node Cells
The radioactive disintegrations per minute per lymph nodes for each individual animal and the stimulation index are given in Table 2. The Stimulation Index expressed as the mean radioactive incorporation for each treatment group divided by the mean radioactive incorporation of the vehicle control group are as follows:
Concentration(%vlv) inacetone/oliveoi.1 4:1 |
Stimulation Index |
Result |
25 |
13.61 |
Positive |
50 |
17.65 |
Positive |
100 |
18.27 |
Positive |
Clinical Observations and Mortality Data There were no deaths. No signs of systemic toxicity were noted in the test or control animals during the test.
Bodyweight: Bodyweight changes of the test animals between Day 1 and Day 6 were comparable to those observed in the corresponding control group animals over the same period.
Applicant's summary and conclusion
- Conclusions:
- The test material was considered to be a sensitiser under the conditions of the test.
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