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Diss Factsheets
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EC number: 255-670-9 | CAS number: 42125-46-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study is comparable to OECD 403 with acceptable restrictions mostly due to reduced documentation (e.g. only mean body weights are reported) and no GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 4-tert-butylcyclohexyl carbonochloridic acid ester
- IUPAC Name:
- 4-tert-butylcyclohexyl carbonochloridic acid ester
- Reference substance name:
- 77/808
- IUPAC Name:
- 77/808
- Details on test material:
- - Name of test material (as cited in study report): 4-tert.-ButylcyclohexylchlorKohlensäureester ( 4-tert-butylcyclohexyl carbonochloridic acid ester)
- Physical state: clear liquid
- Analytical purity: 98 %
- Expiration date of the lot/batch: not reported
- Stability under test conditions: not reported
- Storage condition of test material: not reported
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Breeder MUS RATTUS, Brunntahal (Germany)
- Weight at study initiation: males: 187 +/- 4; females: 185 +/- 5
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 2
- Humidity (%): 55 +/- 5
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose/head only
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: Animals are fixed in class tubes with their snout produding into the inhalation chamber
- System of generating particulates/aerosols: The test atmospere was generated by mixing a continious flow (infusion pump) ot the test substance liquid with compressed air (1.5 bar) employing a jet nozzel.
TEST ATMOSPHERE
- Brief description of analytical method used: The test substance in the test atmosphere was traped in 35 g ethanol. The chlorformate was than hydrolized and the delibarated chloride ions were electrochemical determinded (electrode).
- Samples taken from breathing zone: yes
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 3.58; 1.18, 1.09; 0.88; 0.72 mg/l (measured)
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
Weighing at the beginin, after 7 days and after 14 days
Observations: several times at the day of exposure, once daily afterward except week end and holydays.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, mean body weight (per dose and sex) - Statistics:
- The LC 50 value was calculated by probit analysis
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 0.72 - < 0.88 mg/L air
- Exp. duration:
- 4 h
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- > 0.72 - < 0.88 mg/L air
- Exp. duration:
- 4 h
- Sex:
- female
- Dose descriptor:
- LC50
- Effect level:
- 0.93
- 95% CL:
- 0.84 - 1.02
- Exp. duration:
- 4 h
- Mortality:
- Mortality was observed (see Remarks)
- Clinical signs:
- other: At 0.88 to 3.58 mg/l/4h attempts to escape, salivation dyspnoea, anaemic pallor, apathy, red discharge from eyes and nose, alopecia wer recorded At 0.72 mg/l/4h: dyspnoea, red discharge from eyes and nose and smeared fur were observed The surviving anima
- Body weight:
- Body weight gain of all surviving animals was positive at the termination of the study
- Gross pathology:
- sacreficed animals: no substance related obsevation
animals died: haemorhagic lung, lung edema, reddening of the nasal mucosa
Any other information on results incl. tables
Mortality
Concentration mg/l |
male |
female |
|
analytical |
nominal |
||
3.58 |
19.6 |
10/10 |
10/10 |
1.18 |
3.43 |
10/10 |
9/10 |
1.09 |
5.39 |
10/10 |
8/10 |
0.88 |
2.25 |
10/10 |
5/10 |
0.72 |
1.18 |
0/10 |
0/10 |
Applicant's summary and conclusion
- Executive summary:
The study is comparable to OECD 403 with acceptable restrictions mostly due to reduced documentation (e.g. only mean body weights are reported) and no GLP. Animals tried to escape from exposure. Salivation dyspnoea, anaemic pallor, apathy, red discharge from eyes and nose and alopecia were observed. Animals that died after exposure died with in the first 24 h and showed haemoragic and edematous lungs at necropsy. The animals recovered completely within 9 days. There was no finding at necropsy at the termination of the study.
Conclusion
A LC50 value of >0.72 - < 0.88 mg/l/4h for tert-Butylcyclohexyl-chlorformate aerosol was determined in this study. The substance therefor is classified as toxic after inhalation.
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