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Diss Factsheets
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EC number: 236-826-5 | CAS number: 13499-05-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
In vitro mutagenicity: on the basis of annex XI-1, testing is scientifically not justified: bacterial mutagenesis assays of inorganic metal compounds are frequently negative due to limited capacity for uptake of metal ions. The high prevalence of false negatives for metal compounds might suggest that mutagenesis assays with mammalian cells, as opposed to bacterial cells, would be the preferred starting point for testing for this class of Annex VII substances.
But, as the registered substance is not stable and degrades instantaneously, testing for genotoxicity in general is not possible. The substance needs to be estimated considering the toxicity of its degradation products. HfOCl2 and HfO2, by read across with ZrOCl2 and ZrO2 (see justification for read across in toxicological summary section 7) are considered as not hazardous substances and are not classified at all for human health effects. ZrO2 was especially tested in vitro with bacteria and mamalian cells and all tests were negative for genotoxicity (Ames, mouse lymphoma assay, chromosomic aberation and comet assay).
HCl is not classified for genotoxicity (REACh 2010 registration).
For all these reasons, no study was performed for genotoxicity with HfCl4 and all concerned endpoints are waived.
Endpoint Conclusion:
Justification for classification or non-classification
Hafnium tetrachloride undergoes rapid degradation in presence of water or humidity, it is therefore not stable in contact of moist skin or mucous membranes and degrades in HCl and in an equilibrium of HfOCl2 / HfO2.
Testing HfCl4 for genotoxicity is for this reason not relevant at all, in the same way, no classification is needed.
Nevertheless, degradation products have to be considered, and they are already classified :
- Hydrogen chloride was registered in the frame of REACh in 2010, and is not classified for genotoxicity,
- HfOCl2 and HfO2, by read across with ZrOCl2 and ZrO2 (see justification for read across in toxicological summary section 7) are considered as not hazardous substances and are not classified at all for human health effects.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.