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Diss Factsheets
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EC number: 500-105-6 | CAS number: 39423-51-3 1 - 6.5 moles propoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics, other
- Type of information:
- other: Qualitative judgement on the toxicokinetic behaviour based on physico-chemical characteristics
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Materials and methods
- Objective of study:
- toxicokinetics
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- This qualitative judgement on the toxicokinetic behaviour based on physico-chemical characteristics follows the recommendations of ECHA (ECHA Endpoint specific guidance, Chapter R.7c; Section R.7.12.2.1)
- GLP compliance:
- no
Test material
- Test material form:
- liquid
- Details on test material:
- Name of test material: Trimethylolpropanepoly(oxypropylene)triamine
EC no.: 500-105-6
CAS no.: 39423-51-3
Physical state: clear colourless liquid
Constituent 1
- Radiolabelling:
- no
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Oral absorption:
Following the pKa of the substance (pKa = 10.25), the predominant form in biological system will be the undissociated form. Since the substance is a liquid, relatively small (MW = 440) and highly water soluble (562 g/L), it is expected to readily dissolve into gastrointestinal fluids. As the Log Kow is -1.13, passive diffusion might occur. Therefore, an oral absorption between 50% and 100% is expected.
Respiratory absorption:
As the substance is liquid at room temperature, with a high boiling point (> 235°C) and a low vapour pressure (0.0023 Pa at 20°C), no or only a limited number of airborne particles are expected. The substance is highly water soluble. As a consequence, the substance will be readily soluble in blood and a high amount of the substance will be absorbed per breath. Hydrophilic substances are effectively removed from the air in the upper respiratory tract. Since the substance has a moderate Log Kow value (-1.13) absorption might occur. As a worst case estimation: a 100% respiratory absorption is proposed.
Dermal absorption:
The substance is very hydrophilic (water solubility = 562000 mg/L and Log Pow =-1.13). Therefore it is expected that the penetration into the stratum corneum and hence dermal absorption will be limited. The substance has weak surface active properties, which might enhance dermal absorption slightly. It is generally accepted that dermal absorption will not be higher than oral absorption. As a default of 100% skin absorption is suggested for substances with a molecular weight below 500, the dermal absorption factor is set at 50 -100 % as for oral absorption. - Details on distribution in tissues:
- Wide distribution throughout the body is to be expected as the substance is a relatively small, highly watersoluble molecule. It will diffuse through aqueous channels and pores. Due to its hydrophilic behaviour, uptake into cells might be limited.
- Details on excretion:
- Excretion via urine is expected, as the substance is highly water soluble and has a relatively small MW. However, ionisation at the pH of urine will be very limited as pKa is 10.25.
Metabolite characterisation studies
- Metabolites identified:
- not specified
- Details on metabolites:
- not specified
Applicant's summary and conclusion
- Conclusions:
- A qualitative assessment on the toxicokinetic behaviour was performed on the basis of physico-chemical characteristics.
The substance is relatively small (MW = 440), very water soluble, and hydrophilic. The substance has weak surface active properties and causes mild irritation to skin and serious eye damage.
An absorption factor of 100% is proposed for inhalation and 50-100% for oral and dermal absorption.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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