4-Methylsulfonyl-2-nitro benzoic acid

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

July 8, 2009 - July 10, 2009

Reliability:

1 (reliable without restriction)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2009

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: DS/EN 14669 (1999): Water Quality - Determination of acute lethal toxicity to marine copepods (Copepoda, Crustacae)

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

4-methanesulfonyl-2-nitrobenzoic acid

EC Number:

601-017-1

Cas Number:

110964-79-9

Molecular formula:

C8 H7 N O6 S

IUPAC Name:

4-methanesulfonyl-2-nitrobenzoic acid

Details on test material:

Substance delivered by Cheminova to DHI May 20, 2009. Stored at room temperature.

Test organisms

Test organisms (species):

other: Acartia tonsa

Details on test organisms:

Arcartia tonsa (DANA) has been kept in culture at DHI since 1987. The original culture is from the North Sea, collected by “Danmarks Fiskeriundersøgelser”, DFU.
The test organisms were big copepodits and grown up animals.

Study design

Test type:

static

Water media type:

saltwater

Total exposure duration:

48 h

Test conditions

Test temperature:

19.6+-0.1 C

pH:

7.7

Salinity:

31.6 o/oo

Nominal and measured concentrations:

Nominal: 50; 100; 200; 500; 1000 mg/l

Details on test conditions:

Light/dark period at 16:8 hours

Reference substance (positive control):

yes

Remarks:

3,5-dichlorphenol (3,5-DCP)

Results and discussion

Effect concentrations

Effect concentrations 1

Duration:

48 h

Dose descriptor:

LC10

Effect conc.:

> 1 000 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Remarks on result:

other: No effects were seen

Effect concentrations 2

Duration:

48 h

Dose descriptor:

LC50

Effect conc.:

> 1 000 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Remarks on result:

other: No effects were seen

Details on results:

Oxygen level at the ending of the test was >= 4 mg/l.

Results with reference substance (positive control):

LC50: 0.98 (0.83-1.2) mg/l which is inside the specified interval 0.32-1.68 mg/l
<= 10% of the control animals died during the test.

Applicant's summary and conclusion

Conclusions:

Since no effects were seen, the value of both 10% lethality (LC19) and 50% lethality (LC50) are estimated to be > 1000 mg/l.