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EC number: 701-365-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water and sediment: simulation tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: simulation testing on ultimate degradation in surface water
- Remarks:
- sediment and water test system
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 13. June 1989 to 17. Sep. 1990
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 308 (Aerobic and Anaerobic Transformation in Aquatic Sediment Systems)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 309 (Aerobic Mineralisation in Surface Water - Simulation Biodegradation Test)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 835.4300 (Aerobic Aquatic Metabolism)
- GLP compliance:
- yes
- Radiolabelling:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- natural water / sediment
- Details on source and properties of surface water:
- - Details on collection (e.g. location, sampling depth, contamination history, procedure): Nidda (Altarm), 6230 Frankfurt a.M. 80
- Storage length: 6 days
- pH at time of collection: 6.6
- Redox potential (mv): 186
- Oxygen concentration (mg/l) initial/final: 8.5/4.7
- Biomass (aerobic bacteria/ml): 49
- Water filtered: yes - Details on source and properties of sediment:
- - Details on collection (e.g. location, sampling depth, contamination history, procedure): Nidda (Altarm), 6230 Frankfurt a.M. 80
- Storage length: 6 days
- Textural classification (%sand/silt/clay): 42.1/44.2/13.7
- pH at time of collection: 6.6
- Organic carbon (%): 1.98
- Redox potential (mv) initial/final: 186/163.4
- CEC (meq/100 g): 12.75
- Bulk density (g/cm³): 1.11
- Biomass (e.g. in mg microbial C/100 mg, CFU or other):
- Sediment samples sieved: yes (2 mm sieve) - Details on inoculum:
- the sediment/water sample was suspended and sieved through a 2 mm sieve. Thereafter, the sediment was separated from its water by filtration. The remaining moistness was determined by drying of aliquots. 20 g of the sediment was mixed with 180 g of its respective surface water in a 500 ml ground-neck Erlenmeyer flask. The flasks were kept at 18 to 22 °C in the dark.
- Duration of test (contact time):
- 112 d
- Initial conc.:
- 1 other: mg/kg
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- CO2 evolution
- radiochem. meas.
- Details on study design:
- TEST CONDITIONS
- Volume of test solution/treatment: 0.201 mg/200 g water/sediment
- Composition of medium: 20 g sediment + 180 g surface water
- Solubilising agent: TS was dissolved in methanol; aliquots containing 201 µg Reactive Black 5 in 510 µL were added drop by drop to the sediment/water test system
- Test temperature: 18 °C - 22 °C
- pH: 6.6
- Continuous darkness: yes
TEST SYSTEM
- Culturing apparatus: erlenmeyer flask with a ground neck
- Number of culture flasks/concentration: 20 + 4 reserve
- Method used to create aerobic conditions:
- Method used to create anaerobic conditions:
- Measuring equipment:
- Test performed in closed vessels due to significant volatility of test substance:
- Test performed in open system:
- Details of trap for CO2 and volatile organics if used:
1. glass wool with paraffin oil
2. glass wool
3. soda-lime for adsorption of CO2
4. glass wool
5. soda-lime for adsorption of airborne CO2
SAMPLING
- Sampling frequency: Day 0, 3, 7, 14, 21, 28, 42, 57, 84, 112
SAMPLE PREPARATION
14CO2 was transmitted to a mixture of 2-amino ethanol/methanol and a scintillation cocktail was added, afterwards, the 14CO2 was measured by means of a liquid scintillation counter (LCS). Other volatile radioactivity was measured directly with a LCS after addition of a scintillation cocktail to the glass wool.
The sediment was separated from the surface water by centrifugation. Afterwards, the sediment was extracted with acetonitrile/water (4:1). The extracts were pooled and adjusted to a defined volume. Aliquots of the extract and of the water phase were mixed with a scintillation cocktail and the radioactivity was counted. The not extractable radioactivity in sediment was determined by combustion of aliquots of the dried sediment.
PARAMETERS MEASURED:
- Radioactivity in
- Traps for CO2 and volatile metabolites
- Surface water
- Sediment extract
- extracted sediment
- Identity of radioactive residues in water and sediment extraxt
- Assessment of the half life (DT50) of the test substance - Compartment:
- other: water, material (mass) balance
- % Recovery:
- 9
- Compartment:
- other: sediment, material (mass) balance
- % Recovery:
- 85
- Key result
- % Degr.:
- > 95 - < 96
- Parameter:
- radiochem. meas.
- Sampling time:
- 112 d
- Key result
- Compartment:
- entire system
- DT50:
- 2 d
- Remarks on result:
- other: DT50; DT90=3 to 6 days
- Other kinetic parameters:
- first order rate constant
- Transformation products:
- yes
- No.:
- #1
- No.:
- #2
- No.:
- #3
- No.:
- #4
- No.:
- #5
- No.:
- #6
- No.:
- #7
- Details on transformation products:
- - Pathways for transformation: see attachment
- Evaporation of parent compound:
- no
- Volatile metabolites:
- no
- Residues:
- yes
- Details on results:
- MAJOR TRANSFORMATION PRODUCTS
- Range of maximum concentrations in % of the applied amount and day(s) of incubation when observed:
- M1: 10.2% to 19.5% Day 3 ----> 0.9% to 1% Day 112
- M2: 15.9% to 20.4% Day 3 ----> only traces Day 14
- M3: 12.7% to 16.1% Day 3 ----> < 0.1% Days 7 to 21 ----> 0.5% to 2% Day 28 to 57 ----> < 0.1% from Day 84 onwards
- M4: 5.1% to 5.2% Day 0
- M5: 40.3% to 42.5% Days 7 to 14 ----> 1.2% to 1.5% Day 112
- M6: 2.0% to 2.4% from Day 84 onwards
- M7: 1.4% to 1.9% from Day 28 onwards ----> 7.6% to 8.8% Day 42 ----> 2.1% to 2.5% Day 112
- Range of maximum concentrations in % of the applied amount at end of study period: 7% to 17% on 3rd day of incubation
4% to 5% on the 112th day of incubation - Results with reference substance:
- NA
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The test substance was rapidly degraded. Metabolites were bound to sediment in non-extractable form. After about one month, mineralization started.
- Executive summary:
Hoe GG 0062 was applied to a sediment/water test system at a final concentration of 1 mg/kg in the test system. Hoe CG 0062 was very rapidly degraded. The DT50 of the test item was 2 days. After 3 to 6 days, only 10% of the applied TS could be found. All metabolites decreased at the end of the test period to levels around the lower level of quantification. Consequently, an accumulation of metabolites could be excluded. The majority of the metabolites of the TS was deposited in form of non-extractable residues in sediment during test phase. After about 1 month, mineralization of the metabolites started.
Reference
Description of key information
The test substance demonstrated to be rapidly degraded in sediment.
Key value for chemical safety assessment
- Half-life in freshwater sediment:
- 2 d
Additional information
In a GLP-compliant OECD 308 guideline study the test substance rapidly degraded in sediment.
The DT50 of the test item was 2 days. After 3 to 6 days, only 10 % of the applied test substance could be found and after about 1 month, mineralization of the metabolites started.
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