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Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reason / purpose for cross-reference:
read-across: supporting information
Reason / purpose for cross-reference:
read-across source
Reason / purpose for cross-reference:
read-across source
Specific details on test material used for the study:
Esterification products of triglycerides C18 unsaturated with triethanolamine, dimethyl sulfate quaternized*
Key result
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
2.23 mg/L
Nominal / measured:
estimated
Conc. based on:
act. ingr.
Basis for effect:
mobility
Remarks on result:
other: source substance
Remarks:
partially unsaturated TEA-Esterquat
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
6.05 mg/L
Nominal / measured:
meas. (geom. mean)
Conc. based on:
test mat.
Basis for effect:
mobility
Remarks on result:
other: source substance
Remarks:
partially unsaturated TEA-Esterquat

Description of key information

48 h EC50 = 2.23 mg a.i./L (EU method C.2, Daphnia magna); GLP; RL1; read-across: partially unsaturated TEA-Esterquat

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
2.23 mg/L

Additional information

No experimental data on the short-term toxicity to aquatic invertebrates are available for the target substance Esterification products of triglycerides C18 unsaturated with triethanolamine, dimethyl sulfate quaternized. However, reliable relevant data are available for the closely related source substance partially unsaturated TEA-Esterquat. A justification for read-across is attached to iuclid section 13.

 

The 48 hr acute toxicity of partially unsaturated TEA-Esterquat (solvent free) to water flea (Daphnia magna) according to EU Method C.2 (Acute Toxicity for Daphnia) was studied under static conditions.  Daphnids were exposed to control, and partially unsaturated TEA-Esterquat (solvent free) at nominal concentration of 1, 2.2, 4.84, 10.6, 23.4, 51.5, 113 mg test mat./L for 48 hr.  Mortality/immobilization was observed daily. The 48 hour EC50 was 2.23 mg a.i./L. The effect concentration was corrected for the analytical recovery of 93%.

 

In a supporting study, the 48 hr acute toxicity of partially unsaturated TEA-Esterquat (CAS No. 157905-74-3) was investigated in a study conducted according to OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test). Under static conditions Daphnia magna were exposed to control and test chemical at nominal concentration of 0.2, 0.44, 0.97, 2.13, 4.69, 10.3, 22.7 mg/L (mean measured concentration: 0.09, 0.2, 0.43, 0.95, 2.1, 4.6, 10.1 mg/L). The mean concentrations during the test (mean of samples taken at 0 h and 48 h) were between 34.7 % and 51.7 % of nominal (average 44.5 %). Immobilization and sublethal effects were observed daily. The 48 hour EC50 based on mean measured concentrations was 6.05 mg/L.

 

The lowest 48 h EC50 in Daphnia was 2.23 mg a.i./L.