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Diss Factsheets
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EC number: 700-161-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
A study conducted on Zonyl was used as a read across for The Notified Substance (TNS). Zonyl is representative of the composition of TNS. It is a comparable mixture of mono, bis, pyro/poly and trifluoroalkyl phosphates as ammonium salts but which varies in carbon chain length and percentage composition. The carbon chain length varies from 4-12+ i. e. the repeating unit F(CF2) m where m = 4,6,8,10,12+ though m=6 and m=8 dominate the composition on a per weight percentage. As such it is expected that certain properties can be read-across. In this case, the Zonyl surrogate was the test substance administered. Absorption of The Notified Substance (TNS) is expected to be very slow and insignificant by the oral and dermal routes of exposure. In a biopersistence screening study, no effects on mortality, clinical signs, or body weight were observed. Under the conditions of the test, administration of the test substance for 10 consecutive days resulted in limited absorption and retention of fluorine in the blood. There was some absorption and retention of fluorine in the liver, and levels of total fluorine in livers were higher than levels in the blood.
A study conducted on a compositionally similar analogue to TNS but where the counterion was lysine instead of ammonium was used as supporting read-across.TNS ammonium free was administered by oral gavage to male and female rats in a single dose of either 10 mg/kg or 30 mg/kg. Plasma concentrations of the mono, bis and pyro constituents were observed in both sexes at various time points after dosing indicating absorption. These constituents were distributed in plasma, fat and liver tissues of both male and female rats. In all tissues, the highest concentrations were for the bis phosphate constituent. In vivo metabolism was evidenced by the suite of metabolic products 6:2 FTCA, 6:2 FTUCA, PFBA, PFHxA, PFHpA and 5:3 FTCA as quantified in the plasma of both sexes. Plasma concentrations of 6:2 FTOH were not quantified, since they were lower than the limit of detection thus indicating that the rate of metabolism was faster than the rate of formation. A similar toxicokinetic study was performed for 6:2 FTOH dosed orally in male rats at 300 mg/kg. The observed concentrations of metabolites in the two toxicokinetic studies compare reasonably well when the plasma concentrations are normalised to the same oral dose. Thus TNS is readily hydrolysed to 6:2 FTOH in vivo and the alcohol is then subject to the well-known metabolic pathways leading primarily to formation of conjugation products along with minor yields of terminal carboxylic acids. Additional documentation provided within IUCLID supports the read across approach.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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