3,7-dimethyloct-6-en-1-yn-3-ol

Carcinogenicity

Administrative data

Endpoint:

carcinogenicity: oral

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

supporting study

Study period:

No data

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The study was not conducted according to a guideline and not performed according to GLP. The publication is relatively short, however the design of the study seems proper and the results are described clearly.

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Cross-reference 2

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

publication

Title:

Inhibition of rat mammary carcinogenesis by monoterpenoids

Author:

WA Russin, JD Hoesly, CE Elson, MA Tanner and MN Gould

Year:

1989

Bibliographic source:

Carcinogenesis 10(11): 2161-2164 (1989)

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Mammary tumors were induced by a single gastric intubation of 65 mg/kg 7,12-dimethylbenz[a]anthracene (DMBA) (in 0.5 ml sesame oil) 101 6-week-old female Sprague-Dawley rats, of which 50 were treated with 1% oxygenated (+/-)-linalool in diet for 20 weeks (start: 2 weeks before tumor induction). Number of tumors and latency were recorded in both groups to determine if linalool inhibited mammary carcinogenesis.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Linalool

EC Number:

201-134-4

EC Name:

Linalool

Cas Number:

78-70-6

Molecular formula:

C10H18O

IUPAC Name:

3,7-dimethylocta-1,6-dien-3-ol

Details on test material:

- Name of test material (as cited in study report): (+/-)-Linalool (oxygenated)
- Substance type: Monoterpene
- Analytical purity: 96.6%

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

female

Administration / exposure

Route of administration:

oral: feed

Vehicle:

other: powdered Way Lab Blox diet

Analytical verification of doses or concentrations:

no

Duration of treatment / exposure:

20 weeks

Frequency of treatment:

Ad libitum

Post exposure period:

Not relevant

Doses / concentrations

Remarks:

Doses / Concentrations:
1%
Basis:
nominal in diet

No. of animals per sex per dose:

Dose group: 50
Control group: 51

Control animals:

yes, plain diet

Results and discussion

Results of examinations

Relevance of carcinogenic effects / potential:

The chemopreventive potential of linalool was studied, but the substance was found not to possess this ability. Linalool did not increase the tumor frequency when compared to the untreated control group.

Any other information on results incl. tables

Linalool did not significantly extend tumor latency or reduce the total number of tumors observed when compared to controls. Control group animals had an average number of tumours per rat of 2.3, linalool-treated rats 1.9 tumors per rat.

Applicant's summary and conclusion

Conclusions:

Under the conditions of this study, it can be concluded that 20-week exposure to linalool in the diet did not inhibit DMBA induced mammary carcinogenesis.

Executive summary:

This study was conducted to determine if the oxygenated monoterpene (+/-)-Linalool inhibits the mammary carcinogenesis in the rat. Therefore, mammary tumors were induced in 101 female rats, of which 50 were treated with 1% Linalool in the diet shortly before and after induction (total 20 weeks). Number of tumors and tumor latency were recorded in each group.

The results indicate that linalool did not significantly extend tumor latency or reduce the total number of tumors observed when compared to controls. Under the conditions of this study, it was concluded that 20-week exposure to linalool in the diet did not inhibit mammary carcinogenesis and as well did not increase tumor frequency.