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EC number: 267-510-5 | CAS number: 67874-81-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 966
- Report date:
- 1966
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Repeated Insult Patch Test.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- [3R-(3α,3aβ,6α,7β,8aα)]-octahydro-6-methoxy-3,6,8,8-tetramethyl-1H-3a,7-methanoazulene
- EC Number:
- 267-510-5
- EC Name:
- [3R-(3α,3aβ,6α,7β,8aα)]-octahydro-6-methoxy-3,6,8,8-tetramethyl-1H-3a,7-methanoazulene
- Cas Number:
- 67874-81-1
- Molecular formula:
- C16H28O
- IUPAC Name:
- [3R-(3α,3aβ,6α,7β,8aα)]-octahydro-6-methoxy-3,6,8,8-tetramethyl-1H-3a,7-methanoazulene
- Test material form:
- liquid
Constituent 1
Method
- Type of population:
- general
- Ethical approval:
- not specified
- Subjects:
- - Number of subjects exposed: 37 out of 45 completed the program
- Sex: 19 males and 18 females
- Age: 16 participants 16-20 years, 5 participants 21-30 years, 8 participants 31-40 years, 7 participants 41-50 years, 1 participants 51-60 years - Controls:
- yes, solvent control
- Route of administration:
- dermal
- Details on study design:
- The test patch was a one-inch square of Webril (absorbent non-woven cotton fabric) affixed to the center of a 1 x 3-inch strip of adhesive elastic bandage material. The test bandings were specially prepared by Duke Laboratories, Inc. Immediately before application to each subject 0.5mL of sample (5%) was added to the Webril swatch and the bandage was then placed on the subjects upper arm. Six to nine different samples were tested simultaneously on each group of subjects, and the order in which they were applied was rotated from one subject to the next. The subject removed the bandages 24 hours after application. Early in the test program a large number of subjects was similarly tested with 95% ethanol on similar test patches, and a smaller number was tested with similar samples and with alcohol applied under closed patches. The results of these experiments, which are the subject of a separate report demonstrated that closed patch exposures caused frequent strong reactions, even to alcohol alone, and that alcohol on the semi-open test patch adopted caused essentially no irritation. The basic schedule for the large number of tests in the program of which this is a part comprised a series of nine 24-hour exposures on a Monday-Wednesday-Friday sequence for three successive weeks, the reaction to each exposure being scored at the session following and the reaction to the ninth application on Monday of the fourth week. The test patch was applied to the same site each time, unless reaction to sample or tape adhesive rendered this inadvisable, in which case the test patch was either omitted or applied to a fresh site. On Monday of the sixth week challenge patch was applied to a site not previously exposed, and removed after 24 hours. Reactions to challenge were scored on Wednesday and Friday of this week.
Results and discussion
- Results of examinations:
- Under the conditions of the test the compound caused very little primary irritation. None of the 37 subjects was sensitized by the sample.
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of the test the substance was not sensitising.
- Executive summary:
A HRIPT was performed with 5% test substance. 37 subject were dermally exposed. The basic schedule for the large number of tests in the program of which this is a part comprised a series of nine 24-hour exposures on a Monday-Wednesday-Friday sequence for three successive weeks, the reaction to each exposure being scored at the session following and the reaction to the ninth application on Monday of the fourth week. The test patch was applied to the same site each time, unless reaction to sample or tape adhesive rendered this inadvisable, in which case the test patch was either omitted or applied to a fresh site. On Monday of the sixth week challenge patch was applied to a site not previously exposed, and removed after 24 hours. Reactions to challenge were scored on Wednesday and Friday of this week. Under the conditions of the test the compound caused very little primary irritation. None of the 37 subjects was sensitized by the sample. Under the conditions of the test the substance was not sensitising.
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