Registration Dossier
Registration Dossier
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EC number: 613-147-6 | CAS number: 63141-09-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study in accordance with EU / OECD guidelines.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- 1-(1-chlorocyclopropyl)ethan-1-one
- EC Number:
- 613-147-6
- Cas Number:
- 63141-09-3
- Molecular formula:
- C5 H7 Cl O
- IUPAC Name:
- 1-(1-chlorocyclopropyl)ethan-1-one
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- 200 mg/kg bw
2000 mg/kg bw - No. of animals per sex per dose:
- 3
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 300 - < 500 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
Clinical Signs
A dose of 200 mg/kg body weight was tolerated by male and female rats without
mortalities and clinical signs.
At 2,000 mg/kg body weight dazed condition, uncoordinated gait, abdominal position, labored breathing and a good blood supply of the skin of the animals were observed.
The signs started 5 minutes after administration and lasted up to day 2. All females of this group died.
Body Weights
There were no toxicological effects on body weights or on body weight development in males and females.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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