Registration Dossier
Registration Dossier
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EC number: 613-147-6 | CAS number: 63141-09-3
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 11 Jun - 20 Jul 2001
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - Shake Flask Method)
- Version / remarks:
- 92/69
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 1.3
- Temp.:
- 23 °C
- pH:
- 6.7
- Conclusions:
- The partition coefficient in n-octanol/water is log Pow = 1.3, at 23 °C and pH 6.7.
- Executive summary:
In a GLP study according to 92/69/EEC Method A.8, the partition coefficient of the test substance was determined using the shake flask method. The study was analytically monitored via HPLC. The partition coefficient in n-octanol/water is log Pow = 1.3, at 23 °C and pH 6.7.
Reference
Target condition according to guideline: | Actual condition according to the study: | Validity criteria met: |
Shake flask: For the measurement, substance-specific methods are preferred. Analytical methods which may be appropriate are: photometry, gas chromatography and high performance liquid chromatography. | High performance liquid chromatography was used. | yes |
Shake flask: The temperature, the amount of test substance introduced in the test vessels, the volume of each phase in each vessel and the calculated total amount of test substance based on the analytical data shall be stated. | The temperature, the amount of test substance introduced in the test vessels, the volume of each phase in each vessel and the calculated total amount of test substance based on the analytical data are well documented.
| yes |
Shake flask: The pH of the water used and of the aqueous phase during the experiment shall be stated. | The pH of the water used is 6.7. | yes |
Description of key information
In a GLP study according to 92/69/EEC Method A.8, the partition coefficient of the test substance was determined using the shake flask method. The study was analytically monitored via HPLC. The partition coefficient in n-octanol/water is log Pow = 1.3, at 23 °C and pH 6.7.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 1.3
- at the temperature of:
- 23 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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