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EC number: 700-408-5 | CAS number: 103429-90-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1992-07-20 to 1992-07-24
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Although a good quality report and conducted to GLP and documented test parameters are based on specific national guidelines, the purity of test substance is not reported and actual guideline references are not quoted in test report.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
- Remarks:
- The study report includes a statement signed by the study director confirming that the study was conducted in accordance with the principles of Good Laboratory Practice, however the report does not include a GLP certificate issued by an official body (suc
Test material
- Reference substance name:
- 3-Methoxy-3-methylbutyl acetate
- EC Number:
- 700-408-5
- Cas Number:
- 103429-90-9
- Molecular formula:
- C8H16O3
- IUPAC Name:
- 3-Methoxy-3-methylbutyl acetate
- Details on test material:
- - Name of test material (as cited in study report): MMB-AC
- Physical state: Colourless liquid
- Lot/batch No.: 32840
- Storage condition of test material: Stored in the dark, under ambient conditions.
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Interfauna UK Limited, Abbots Ripton Road, Wyton, Huntingdon, Cambs, PE17 2DT
- Weight at study initiation: 3.2-3.3 kg
- Housing: Individual aluminium cages with grid floors beneath which were absorbent paper lined trays
- Food: ad libitum Standard Rabbit Diet, supplied by Special Diets Services Limited, 1 Stepfield, Witham, Essex, CM8 3AD,
- Water: ad libitum tap water
- Acclimation period: 18 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 - 22°C
- Humidity (%): 55
- Air changes (per hr): 15-20
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: One eye was left untreated in each animal, which served as a control.
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) 0.1ml - Duration of treatment / exposure:
- N/A
- Observation period (in vivo):
- 1, 24, 48 and 72 hours after instillation
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): None
- Time after start of exposure: N/A
SCORING SYSTEM: OECD recommended scoring system
TOOL USED TO ASSESS SCORE: Hand held magnifier and pen torch.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 1 hour
- Score:
- ca. 0
- Max. score:
- 0
- Reversibility:
- other: Not applicable - no irritation seen
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- ca. 0
- Max. score:
- 0
- Reversibility:
- other: Not applicable - no irritation seen
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 1 hour
- Score:
- ca. 0.33
- Max. score:
- 1
- Reversibility:
- fully reversible within: 24 hours
- Remarks on result:
- other: Iris score of 1 seen in one animal at 1 hour time point.
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- ca. 0
- Max. score:
- 1
- Reversibility:
- fully reversible within: 24 hours
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 1 hour
- Score:
- ca. 1
- Max. score:
- 1
- Reversibility:
- fully reversible within: 24 hours
- Remarks on result:
- other: Conjunctivae score of 1 seen in all animals at 1 hour time point
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- ca. 0
- Max. score:
- 1
- Reversibility:
- fully reversible within: 24 hours
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 1 hour
- Score:
- ca. 0.33
- Max. score:
- 1
- Reversibility:
- fully reversible within: 24 hours
- Remarks on result:
- other: Chemosis score of 1 seen in one animal at 1 hour time point
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- ca. 0
- Max. score:
- 1
- Reversibility:
- fully reversible within: 24 hours
- Irritant / corrosive response data:
- All rabbits were noted to groom the treated eye immediately after dosing which is indicative of a stinging effect.
No corneal responses were noted. Slight conjunctival redness was noted in all 3 treated eyes at 1 h post instillation. In addition, one treated eye showed a slight iridial response and slight chemosis at 1h. Full recovery of all treated eyes was noted at 24 h post instillation.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Results reviewed with reference to Directive 67/548/EEC. Criteria used for interpretation of results: EU
- Conclusions:
- The test material is slightly irritant to rabbit eyes.
- Executive summary:
The eye irritation potential of a test material, MMB-Ac, was investigated in 3 New Zealand White rabbits. Slight conjunctival redness (score I) was noted in all treated eyes at I h post instillation. In addition, one of the treated eyes showed a slight iridial response and slight chemosis at 1 h. Full recovery was noted at 24 h post instillation. MMB-Ac is slightly irritant to rabbit eyes.
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