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EC number: 211-623-4 | CAS number: 675-62-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The study was conducted similar to an appropriate OECD test guideline, with acceptable restrictions and predates GLP . The restrictions were that the test did not include an additional strain to detect cross-linking mutagens. In view of the lack of genetic toxicity demonstrated in studies on mammalian cells, and the absence of structural features that indicate that such mutagenicity is likely, testing in an appropriate 5th strain is not considered necessary. In addition, the only silicon-containing substance which has given a positive result in a bacterial strain capable of detecting cross-linking or oxidising mutagens contains an epoxy- side-chain (which is associated with cross-linking mutagenicity), and this substance was positive in Salmonella typhimurium strains TA 100, TA 1535 as well as in E.coli WP2uvrA
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Version / remarks:
- (adopted 1997)
- Deviations:
- yes
- Remarks:
- (the test did not include an additional strain to detect cross-linking mutagens; only 4 concentrations instead of 5 stated in the guideline were tested)
- GLP compliance:
- no
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Dichloromethyl(3,3,3-trifluoropropyl)silane
- EC Number:
- 211-623-4
- EC Name:
- Dichloromethyl(3,3,3-trifluoropropyl)silane
- Cas Number:
- 675-62-7
- Molecular formula:
- C4H7Cl2F3Si
- IUPAC Name:
- (dichloromethyl)(3,3,3-trifluoropropyl)silane
- Details on test material:
- - Name of test material (as cited in study report): Dichloromethyl (3,3,3-trifluoropropyl)silane
- Substance type: Chlorosilane
Constituent 1
Method
- Target gene:
- his-operon
Species / strainopen allclose all
- Species / strain / cell type:
- S. typhimurium TA 1538
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Metabolic activation system:
- Aroclor 1254 induced rat liver
- Test concentrations with justification for top dose:
- 0.5, 5, 100, or 500 μl/plate
- Vehicle / solvent:
- The solvent (negative control) for all treament/strains was deionised water, absolute ethanol or dimethylsulfoxide (DMSO).
Controlsopen allclose all
- Untreated negative controls:
- no
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- other: -S9: TA100 and TA1535 (Sodium azide 100 µg/plate), TA1537 (9-Aminoacridine 100 µg/plate) and TA 1538 (2-Nitrofluorene 100 µg/plate).
- Untreated negative controls:
- no
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- other: 2-Anthramine (Anth) +S9: All strains = 100 µg/plate. -S9: TA 98 and TA1538 =100 µg/plate.
- Details on test system and experimental conditions:
- METHOD OF APPLICATION: in agar (plate incorporation)
DURATION
- Exposure duration: 48 hours
NUMBER OF REPLICATIONS: 3 - Evaluation criteria:
- Strains TA 1535, TA 1537 and TA 1538:
If the solvent control value is within the normal range, a chemical that produces a positive dose response over three concentrations with the lowest increase equal to twice the solvent control value is considered to be mutagenic.
Strains TA 98 and TA 100:
If the solvent control value is within the normal range, a chemical that produces a positive dose response over three concentrations with the highest increase equal to twice the solvent control for TA 100 and two to three times solvent control value for strain TA 98 is considered to be mutagenic. For these strains, the dose response increase should start at approximately the solvent control values.
Reproducibility: If a chemical produces a response in a single test that cannot be reproduced in one or more additional runs, the initial positive test data loses significance. - Statistics:
- Not reported
Results and discussion
Test resultsopen allclose all
- Species / strain:
- S. typhimurium TA 1538
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not applicable
- Positive controls validity:
- valid
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not applicable
- Positive controls validity:
- valid
- Additional information on results:
- Not reported
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
Table 1: Overlay plate test results
Test |
Revertants per plate |
||||
TA 1535 |
TA 1537 |
TA 1538 |
TA 98 |
TA 100 |
|
Non-activation |
|
|
|
|
|
Solvent control |
23 |
5 |
38 |
20 |
176 |
Postive control* |
173 |
61 |
294 |
154 |
>103 |
Test material (µl) |
|
|
|
|
|
0.5 |
22 |
3 |
40 |
23 |
142 |
5 |
21 |
6 |
38 |
20 |
160 |
100 |
28 |
4 |
40 |
21 |
164 |
500 |
20 |
4 |
32 |
22 |
114 |
Activation |
|
|
|
|
|
Solvent control |
24 |
7 |
36 |
26 |
181 |
Postive control** |
263 |
97 |
>103 |
>103 |
>103 |
Test material (µl) |
|
|
|
|
|
0.5 |
22 |
6 |
45 |
26 |
191 |
5 |
26 |
4 |
39 |
26 |
197 |
100 |
23 |
4 |
41 |
29 |
183 |
500 |
22 |
3 |
30 |
24 |
156 |
* TA-1535 |
AZ 100 µg/plate |
|
** TA-1535 |
ANTH 100 µg/plate |
|
*TA-1537 |
AZ 100 µg/plate |
|
**TA-1537 |
ANTH 100 µg/plate |
|
*TA-1538 |
NF 100 µg/plate |
|
**TA-1538 |
ANTH 100 µg/plate |
|
*TA98 |
NF 100 µg/plate |
|
**TA98 |
ANTH 100 µg/plate |
|
*TA100 |
AZ 100 µg/plate |
|
**TA100 |
ANTH 100 µg/plate |
|
Solvent |
DMSO 50 µl/plate |
|
Solvent |
DMSO 50 µl/plate |
|
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative with and without metabolic activation
The test item was tested for bacterial mutagenicity (Ames Test) similar to the OECD TG 471 and predates GLP. The Salmonella typhimurium strains TA 1535, TA 1537, TA 1538, TA 98, and TA 100 were exposed to the test material both in absence and presence of a metabolic activation system. An additional strain for the detection of cross-linking agents was not included into the test. No treatment related increase in the number of revertants was observed in any of the tester strains. Appropriate solvent and positive controls were included into the test and gave the expected results. Hence, the test item was considered to be non-mutagenic to bacteria under the conditions of the test.
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