Dichloromethyl(3,3,3-trifluoropropyl)silane

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Only an abstract was available for review.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1967

Report date:

1967

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

2.0 ml/kg bw of the undiluted test material were applied to the intact abdominal skin of two albino rabbits. Each sample was introduced under a binder previously placed around the truck of the animal and secured with staples. The trunks of the animals were wrapped securely with gauze and adhesive tape to keep the binder and test material in contact with the skin and to prevent ingestion of the applied material. After an exposure period of 24 hours the binders were removed and any unabsorbed material remaining on the skin was removed by gentle sponging with a moistened towel. The rabbits were examined for gross signs of irritation and systemic toxicity from pre-cutaneous absorption at the end of the exposure period and twice weekly for a total of two weeks. Irritative effects are scored by the method of draize. At the conclusion of the study the animals were sacrificed.

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Dichloromethyl(3,3,3-trifluoropropyl)silane

EC Number:

211-623-4

EC Name:

Dichloromethyl(3,3,3-trifluoropropyl)silane

Cas Number:

675-62-7

Molecular formula:

C4H7Cl2F3Si

IUPAC Name:

(dichloromethyl)(3,3,3-trifluoropropyl)silane

Details on test material:

- Name of test material (as cited in study report): Trifluoropropyl(methyl)dichlorosilane
- Substance type: Chlorosilane
- Physical state: Clear colourless liquid
- Lot/batch No.: TX183A

Test animals

Species:

rabbit

Strain:

other: Albino

Sex:

not specified

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Maxfield animal supply, Ohio, USA

Administration / exposure

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Duration of exposure:

24 hours

Doses:

2.0 ml/kg bw

No. of animals per sex per dose:

2

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

approximate LD50

Effect level:

ca. 2 mL/kg bw

Based on:

test mat.

Remarks on result:

other: limit test, mortality: 1/2

Clinical signs:

other: Severe skin irritation characterised by sloughing of skin, bleeding, fissures and serious oozing was observed in both animals.

Applicant's summary and conclusion

Conclusions:

A fairly limited report of a generally well conducted study that predates GLP, identified a estimated dermal LD50 value of 2.00 mL/kg bw.