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EC number: 248-502-0 | CAS number: 27503-81-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 17.08.2012 - 19.10.2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- GLP compliance:
- yes (incl. QA statement)
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- Sample solutions at pH 4, 7 and 9 were maintained at 50.0 ± 0.5 °C for a period of 8 days. The sample solutions were taken from the water bath at various times and the pH of each solution recorded.
Samples
An aliquot of each sample solution was diluted by a factor of 2 using acetonitrile (MeCN). Sample dilutions performed under non-actinic light. - Buffers:
- Buffer solution for
pH 4: Potassium hydrogen phthalate 0.05 mol/dm3
pH 7: Disodium hydrogen orthophosphate (anhydrous) 0.03 mol/dm3, Potassium dihydrogen orthophosphate 0.02 mol/dm3 and Sodium chloride 0.02 mol/dm3
pH 9: Disodium tetraborate 0.01 mol/dm3 and Sodium chloride 0.02 mol/dm3
These solutions were subjected to ultrasonication and degassing with nitrogen to minimize dissolved oxygen content. - Details on test conditions:
- The test item is dissolved in an aqueous solution at a specific pH value and incubated in the dark in a water bath thermostated at a specific temperature with a maximum deviation of ± 0.5 °C. The concentration of the test item is determined as a function of time, using a suitable analytical method. In the case of decreasing concentrations, the logarithms of the concentrations are plotted against time (log 10 (c t )). If the plot is a straight line, the reaction is considered to be of (pseudo-)first order. The rate constant and the half-life time are then calculated using the slope. From data generated at differing temperatures for any single pH, an estimation of the rate constant and half-life at 25 °C can be determined by the use of the Arrhenius relationship.
Sample solutions were prepared in stoppered glass flasks at a nominal concentration of 5 x 10-2 g/L in the three buffer solutions. Sample preparation was performed under non-actinic light.
The concentration of each solution did not exceed the lesser of 0.01 mol/L or half the water solubility.
The test solutions were split into individual vessels for each data point.
The solutions were shielded from light whilst maintained at the test temperature. - Duration:
- 8 d
- pH:
- 4
- Temp.:
- 50
- Initial conc. measured:
- >= 0.054 - <= 0.054 g/L
- Duration:
- 8 d
- pH:
- 7
- Temp.:
- 50
- Initial conc. measured:
- >= 0.051 - <= 0.051 g/L
- Duration:
- 8 d
- pH:
- 9
- Temp.:
- 50
- Initial conc. measured:
- >= 0.051 - <= 0.051 g/L
- Number of replicates:
- Experiments were run in duplicates at each pH with test sample and standard.
- Negative controls:
- yes
- Remarks:
- MeCN : relevant buffer solution (1:1 v/v)
- Preliminary study:
- In a preliminary study at 50 °C at pH 4, 7 and 9 for 198 hours no significant hydrolysis (<10 %) has been observed, equivalent to a half-life of more than 1 year at 25 °C. Normally the tier 1 test would involve incubation for a period of 5 days; however, due to a sampling error no usable data was available for the 5 day time point. A subsequent time point taken after 8 days showed less than 10 % hydrolysis. As less than 10 % hydrolysis at 50 °C over 5 days equates to a half-life of greater than one year at 25 °C, the same conclusion can be drawn from less than 10 % hydrolysis over the longer period of 8 days.
- Transformation products:
- not measured
- Key result
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Key result
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Key result
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Validity criteria fulfilled:
- yes
- Conclusions:
- The test substance is hydrolytically stable under environmental conditions (half-life >1 year at pH 4, 7 and 9) and abiotic degradation is not expected.
- Executive summary:
The assessment of hydrolytic stability of the test item (CAS 27503-81-7) was carried out using a procedure designed to be compatible with Method C.7 Abiotic Degradation, Hydrolysis as a Function of pH of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 111 of the OECD Guidelines for Testing of Chemicals, 13 April 2004. The results are as follows:
pH 4 Estimated half-life at 25 °C is >1 year
pH 7 Estimated half-life at 25 °C is >1 year
pH 9 Estimated half-life at 25 °C is >1 year
Reference
The linearity of the detector response with respect to concentration was assessed over the concentration ranges of 1.06 to 53.1 mg/L in pH 4 media, 1.17 to 58.7 mg/L in pH 7 media and 1.05 to 52.6 mg/L in pH 9 media. These were satisfactory with correlation coefficients of 0.999, 1.000 and 1.000 being obtained, respectively.
Description of key information
The test substance is hydrolytically stable under environmental conditions (half-life >1 year at pH 4, 7 and 9) and abiotic degradation is not expected.
Key value for chemical safety assessment
Additional information
The assessment of hydrolytic stability of the test item (CAS 27503-81-7) was carried out using a procedure designed to be compatible with Method C7 Abiotic Degradation, Hydrolysis as a Function of pH of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 111 of the OECD Guidelines for Testing of Chemicals, 13 April 2004. The results are as follows:
pH 4 Estimated half-life at 25 °C is >1 year
pH 7 Estimated half-life at 25 °C is >1 year
pH 9 Estimated half-life at 25 °C is >1 year
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