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EC number: 219-842-7 | CAS number: 2550-02-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 01-10-1991 to 08-10-1991
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- dose volume exceeded
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Triethoxypropylsilane
- EC Number:
- 219-842-7
- EC Name:
- Triethoxypropylsilane
- Cas Number:
- 2550-02-9
- Molecular formula:
- C9H22O3Si
- IUPAC Name:
- triethoxy(propyl)silane
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Bor: WISW (SPFCpb)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Winkelmann Versuchstierzucht GmbH & Co. KG., D-4799 Borchen.
- Age at study initiation: 8 weeks (males) and 9 weeks (females)
- Weight at study initiation: 147-165 g (males) and 132-142 g (females)
- Fasting period before study: Approx. 16 hours before treatment
- Housing: Macrolon cages, type II. One animal per cage. Animal bedding chips, supplied by Jelu-Werk, J. Ehrler, Industriemehule, D-7092 Rosenberg/Württ.
- Diet: Standard diet ad libitum, ssniff R, Special diet for rats.
- Water: Water was provided ad libitum in drinking water quality from Stadtwerke Bielefeld, using an automatic drinking water system with drinking nipples.
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20.5 – 22.5
- Humidity (%): 40-70
- Photoperiod (hrs dark / hrs light):12/12
IN-LIFE DATES: From: 01-10-1991 To: 15-10-1991
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- peanut oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 237 mg/mL
- Justification for choice of vehicle: substance is insoluble in water.
- Lot/batch no. (if required): 8249
MAXIMUM DOSE VOLUME APPLIED: 21.5 mL/kg (guideline: <= 1 mL/100 g bw)
DOSAGE PREPARATION (if unusual): prepared as emulsion before dosing - Doses:
- 5110 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: The animals were continuously observed for first 4 to 6 hours after administration and then once daily. The nature of the toxicity as well as the onset, the intensity, and the duration of the signs were recorded. Mortality was checked twice daily (a.m. and p.m.), on weekends only once. The body weights were recorded at the beginning and also 7 and 14 days after administration
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, organ weights, histopathology, body orifices, body cavities (thoracic and abdominal), and their content. - Statistics:
- None given.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 110 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occurred during the study period.
- Clinical signs:
- other: Signs of toxicity were restrained gait, slight to moderate clonic convulsions, slight to moderate mydriasis, and diarrhea in male and female rats. In additions , male animals showed slight hypokinesia, chromoacryorrhea, and piloerection. In one female ani
- Gross pathology:
- Necropsy and histopathological examinations revealed no substance-related findings
Any other information on results incl. tables
Table 2. Body weights (g) – Individual Values.
Dose (mg/kg bw) |
Animal No. |
Day 0 |
Day 7 |
Day 14 |
Male animals |
|
|
|
|
5110 |
1 |
165 |
224 |
243 |
2 |
154 |
215 |
237 |
|
3 |
147 |
202 |
227 |
|
4 |
149 |
201 |
224 |
|
5 |
152 |
203 |
226 |
|
Female animals |
|
|
|
|
5110 |
6 |
142 |
160 |
162 |
7 |
136 |
173 |
171 |
|
8 |
136 |
160 |
159 |
|
9 |
135 |
174 |
173 |
|
10 |
132 |
148 |
149 |
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP/EU GHS criteria are not met, no classification required according to Regulations (EC) No 1272/2008
- Conclusions:
- In an acute oral toxicity study conducted in rats according to the now deleted OECD 401 and in compliance with GLP, the LD50 for triethoxypropylsilane was greater than 5110 mg/kg bw.
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