Registration Dossier
Registration Dossier
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EC number: 906-265-7 | CAS number: -
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- other: abstract
- Title:
- Comparative pharmacokinetics and metabolism of ethylene glycol in pregnant rats and rabbits.
- Author:
- Carney, E.W., Pottenger, L.H., Bartels, M.J., Jaeckh, R., Quast, J.F.
- Year:
- 1 998
- Bibliographic source:
- Toxicology Letters 95, 208
Materials and methods
Test material
- Reference substance name:
- Ethane-1,2-diol
- EC Number:
- 203-473-3
- EC Name:
- Ethane-1,2-diol
- Cas Number:
- 107-21-1
- Molecular formula:
- C2H6O2
- IUPAC Name:
- 1,2-ethanediol
- Reference substance name:
- ethan-1,2-diol
- IUPAC Name:
- ethan-1,2-diol
Constituent 1
Constituent 2
Test animals
- Species:
- other: rat and rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Duration and frequency of treatment / exposure:
- gd 10 rats and gd 9
Doses / concentrations
- Remarks:
- Doses / Concentrations:
500 or 2500 mg/kg
Results and discussion
Toxicokinetic / pharmacokinetic studies
Toxicokinetic parameters
- Toxicokinetic parameters:
- other: Key findings were: (1) maternal blood concentrations of EG were comparable in rats and rabbits; (2) levels of GA in maternal blood and EEF were 3 to 36-fold lower in rabbits than in rats; (3) in rats, concentrations of GA were higher in EEF than in matern
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
