Registration Dossier
Registration Dossier
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EC number: 906-265-7 | CAS number: -
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
monoethylene glycol: 7day NOEC=15380.
QSAR values: 2630, 7690, 2050mg/l respectively (30 day Chv values) for MEG, DEG and NaAc.
Key value for chemical safety assessment
Additional information
There is chronic toxicity data on only one of the three constituents of this substance but the one that is likely to represent the most toxic component. The study does not however meet current requirements for this end point; it presents a NOEC but is only a 7 day study. QSAR data suggests that the toxicity decreases with increasing molecular weight and therefore that monoethylene glycol is likely to be the most toxic species. The QSAR does not include a specific class covering acetate salts but predicts that the same neutral organics class can be used as an alternative. The QSAR predicts that sodium acetate will be of similar toxicity to MEG, which confirms that the reliable measured data from MEG could be used as a conservative alternative to predict the overall toxicity of the substance. Overall, it is clear that all of the components present very low chronic toxicity. A weight of evidence approach suggest that a 28 day NOEC is likely to be well in excess of 1000mg/l. However, this end point is formally waived as it is not necessary to have data available for this end point to derive a PNEC and consequent RCRs that shows safe use.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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