1-(2-bromo-4-chloro-phenyl)-4-(trifluoromethyl)triazole

Partition coefficient

Administrative data

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Study period:

21 Apr - 30 Apr 2022

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2022

Report date:

2022

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

EU Method A.23 Partition Coefficient (1-Octanol/Water): Slow-Stirring Method

Version / remarks:

2006

Test guideline 2

Qualifier:

according to guideline

Guideline:

OECD Guideline 123 (Partition Coefficient (1-Octanol / Water), Slow-Stirring Method)

Version / remarks:

2006

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

slow-stirring method

Partition coefficient type:

octanol-water

Test material

Test material information

Constituent 1

Reference substance name:

1-(2-bromo-4-chlorophenyl)-4-(trifluoromethyl)-1H-1,2,3-triazole

EC Number:

863-757-3

Cas Number:

1445866-55-6

Molecular formula:

C9H4BrClF3N3

IUPAC Name:

1-(2-bromo-4-chlorophenyl)-4-(trifluoromethyl)-1H-1,2,3-triazole

Study design

Analytical method:

gas chromatography

Results and discussion

Partition coefficient

Key result

Type:

log Pow

Partition coefficient:

3.48

Temp.:

25 °C

Remarks on result:

other: Method is seen to be precise also for values below 4.

Details on results:

The partition coefficient was calculated based on the results of the analytical determinations. The test item content was determined by GC-ECD. The log Pow was calculated for each sampling separately.
The weighted standard deviation between the three different replicates was ≤ 0.0114. Therefore, the study is considered to be valid.
According to this study, the logarithmic partition coefficient (n octanol/water) of the test item was determined to be 3.48 using the slow stirring method at 25 °C ± 0.5 °C.
The slow stirring method is seen to be precise also for partition coefficient values below 4.

Any other information on results incl. tables

 

Sample Description	absolute amount test item per Replicate measured	absolute amount test item per Replicate nominal	cow/cw	log Po/w
	[mg]	[mg]
Replicate 1	11.160	10.716	3305.142	3.52
Replicate 1	11.436	10.716	3334.601	3.52
Replicate 1	10.391	10.716	2994.568	3.48
Replicate 1	10.725	10.716	3025.721	3.48
Replicate 1	11.119	10.716	3143.963	3.50
Replicate 1	11.157	10.716	3174.050	3.50
Replicate 2	11.321	10.716	3236.501	3.51
Replicate 2	10.427	10.716	2964.883	3.47
Replicate 2	10.326	10.716	2901.513	3.46
Replicate 2	9.923	10.716	2847.425	3.45
Replicate 2	9.572	10.716	2703.174	3.43
Replicate 2	10.613	10.716	3021.993	3.48
Replicate 3	10.719	10.716	3091.683	3.49
Replicate 3	11.141	10.716	3215.734	3.51
Replicate 3	10.325	10.716	2915.774	3.46
Replicate 3	9.001	10.716	2554.615	3.41
Replicate 3	10.038	10.716	3002.898	3.48
Replicate 3	10.242	10.716	2816.024	3.45

Applicant's summary and conclusion

Conclusions:

According to this study, the logarithmic partition coefficient (n octanol/water) of the test item was determined to be 3.48 using the slow stirring method at 25 °C ± 0.5 °C.

Executive summary:

Test Method: The partition coefficient of the test item was determined using the Slow Stirring Method.

Results: The partition coefficient was calculated based on the results of the analytical determinations. The test item content was determined by GC-ECD. The log P_ow was calculated for each sampling separately. The weighted standard deviation between the three different replicates was ≤ 0.0114. Therefore, the study is considered to be valid. According to this study, the logarithmic partition coefficient (n‑octanol/water) of the test item was determined to be 3.48 using the slow stirring method at 25 °C ± 0.5 °C.

Discussion: The slow stirring method is seen to be precise also for partition coefficient values below 4.