Registration Dossier
Registration Dossier
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EC number: 221-650-3 | CAS number: 3177-22-8
Endpoint summary
Administrative data
Description of key information
Low acute toxicity.
Key value for chemical safety assessment
Additional information
Few data is available in literature on the acute toxicity of target substance. No information on test methods and results is availble, however, available data is consistent and indicates a low acute toxicity. In particular, lethal doses (LD) above 10000 mg/kg and above 15000 mg/kg are reported for rat and mouse upon oral exposure; a LD50 of 4975 mg/kg is reported upon intraperitoneal exposure in mouse (ref. Meditsina Truda i Promyshlennaya Ekologiya. Industrial Medicine and Ecology., (10)(36), 1996).
Available data on structural analogues is also examined.
As for the acid form of test substance (CAS 88 -63 -1, EC 201 -846 -5), a LD50 of 3480 mg/kg in rat upon oral exposure is reported (ref. Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972 Vol. -, p. 180, 1972).
Moreover, an experimental data is available on a structural analogue, i.e. 4-aminobenzenesulphonic acid (CAS 121-57-3, EC 204-482-5); a LD50 of 12300 mg/kg is found for rats exposed by oral route (ref. Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972Vol. -, p. 180, 1972).
Justification for classification or non-classification
Available experimental data on target substance as well as on structural analogues of target substance was examined.
LD50 values by oral route were all above the threshold value of 2000 mg/kg for classification within the CLP Regulation (EC 1272/2008), thus no classification is proposed.
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