Registration Dossier
Registration Dossier
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EC number: 806-451-7 | CAS number: 42532-60-5
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
The parent was not tested for technical reasons (hydrolytic instability). 72-hr EC50, growth rate, of the hydrolysis product: >100 mg/L (nominal) (OECD 201). 72-hour NOEC, 10 mg/L.
Key value for chemical safety assessment
Additional information
C4 fluorinated isonitrile is gas which, to the extent it dissolves in water, is hydrolytically unstable. We have proposed adaptation of the testing requirement for toxicity to aquatic algae and cyanobacteria, substituting direct testing of the hydrolysis product. The key study, with Pseudokirchneriella subcapitata, was conducted as per guideline OECD 201 with analytical confirmation of the tested dose. Since measured concentrations were within 80% of nominal, the results were reported on a nominal concentration basis. The 72-hour EC50 of the heptafluoroisobutyramide hydrolysis product was >100 mg/L, the highest concentration tested. The 72-hour NOEC was 10 mg/L based on a statistically but not biologically significant 6% inhibition of growth rate at 100 mg/L. In a supporting, non-guideline study with Pseudokirchneriella subcapitata, the 72-hour NOEC (biomass) of the hydrolysis product was 100 mg/L (nominal concentration, highest tested).
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