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EC number: 602-997-3 | CAS number: 124495-18-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Phototransformation in water
Administrative data
Link to relevant study record(s)
- Endpoint:
- phototransformation in water
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Study type:
- direct photolysis
- Qualifier:
- according to guideline
- Guideline:
- EPA Guideline Subdivision N 161-2 (Photodegradation Studies in Water)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: BBA Guideline IV/6-1 (Aqueious Photolysis)
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- - Radiolabeled test substance name: 14C-XDE-795
- Label: Labeled in the 2 position of the quinoline ring
- Purity: 99+%
- Reference no. A925-161 - Radiolabelling:
- yes
- Analytical method:
- high-performance liquid chromatography
- other: liquid scintillation counting
- Light source:
- Xenon lamp
- Light spectrum: wavelength in nm:
- 298
- Duration:
- 8 h
- Temp.:
- 20 °C
- Initial conc. measured:
- 10 mg/L
- Reference substance:
- yes
- Remarks:
- DCHQ
- Dark controls:
- yes
- Key result
- % Degr.:
- 27
- St. dev.:
- 12
- Sampling time:
- 45 min
- Test condition:
- 298 ± 8 nm and 20°C [solvent:acetonitrile:water (80:20 v/v)]
- Quantum yield (for direct photolysis):
- 0.012
- Key result
- DT50:
- > 1.7 - < 22.8 h
- Remarks on result:
- other: The half-lives (medium values assuming normal climate conditions) were between 1.7 (June) and 22.8 h (December)
- Transformation products:
- yes
- Remarks:
- One main radio-labeled component was found which contained between 6 and 30% of the radioactivity (was not identified). A minor degradation product (1-11 % of the initial radioactivity) corresponding to 5,7-dichloro-4-hydroxyquinoline
- Validity criteria fulfilled:
- yes
- Conclusions:
- Analysis of irradiated 14C-test substance solutions indicated the presence of two main photoproducts. The major product, which accounted between 6 and 30% of the radioactivity after 8 hours irradiation, was not identified during this study. A second product, 5,7-dichloro-4-hydroxyquinoline, which accounted for 1-11% of the radioactivity after 8 hours was identified by chromatographic comparison with an analytical standard.
- Executive summary:
The degree of photolytic degradation and the quantum yield of the test substance were determined by irradiation at 298 ± 8 nm at 20°C in accordance with BBA guideline IV/6-1 (aqueous photolysis). Due to the low solubility of the test substance in water, the irradiations were performed in a mixture of acetonitrile and purified, de-ionized water (80:20 v/v), after showing that the acetonitrile had no effect on light absorption. HPLC analysis showed that test substance was degraded under these conditions (between 15 and 44 % within 45 min depending on concentration and lamp intensity). The quantum yield of the photodegradation was determined to be 1.2E-2 (±19%; n = 4; independent from concentration and lamp intensity).
Additionally, 14C-test substance was irradiated under the same conditions. Samples were analyzed by radio-HPLC after irradiation times of 4 to 8 h (with different lamp intensities). Test substance accounted for 55-93% of the radioactivity and one main radio-labeled component was found which contained between 6 and 30% of the radioactivity. This degradate was not identified within this study. A minor degradation product (1-11 % of the initial radioactivity) corresponding to 5,7-dichloro-4-hydroxyquinoline was identified by chromatographic comparison with an analytical standard.
Environmental half-life periods were predicted using a computer program. The determined UV/Vis absorption coefficients and quantum yield were used as input and no dissipation processes other than photolysis were considered. The half-lives (medium values assuming normal climate conditions) were between 1.7 (June) and 22.8 h (December).
Reference
Description of key information
Half-life = 18 minutes at 40ºN summer sunlight. CFBPQ (2-chloro-10-fluoro[1]benzopyrano[2,3,4-de]quinoline) was identified as the primary photodegradate of the test substance.
CFBPQ is formed very quickly under natural conditions. Once formed there is a rapid degradation of CFBPQ to material which is polar and multicomponent in nature. When sediment is present the amount of radioactivity present in the aqueous layer is greatly reduced due to partitioning of CFBPQ to the sediment.
Key value for chemical safety assessment
- Half-life in water:
- 18 min
Additional information
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