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EC number: 478-920-0 | CAS number: 457632-32-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23. January - 05. June 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Name Nomcort HK-P
Batch no. 7-4-C
Appearance white/pale yellow waxy solid
Composition Polyglyceryl-10 Behenate / Eicosadioate
CAS No. 457632-32-5
EINECS-No. 478-920-0
Purity 100%
Homogeneity homogeneous
Volatility 0.00000001 hPa (20°C)
Stability H2O: unknown; EtOH: unknown; acetone: unknown; CH3CN: unknown; DMSO: unknown
Solubility H2O: 0.1-1 g/L; EtOH: unknown; acetone: unknown; CH3CN: unknown; DMSO: unknown
Production date 17. Apr. 2017
Expiry date 17. Apr. 2020
Storage Room Temperature (20 ± 5°C) - Analytical monitoring:
- yes
- Details on sampling:
- The DOC content of the test item in the test vessels was measured at the beginning and at the end of the test.
- Vehicle:
- no
- Details on test solutions:
- Dilution water (Daphnia medium) with the following specification is used
Parameter Concentration in mg/L
CaCl2*2H2O 293.80
MgSO4*7H2O 123.30
NaHCO3 64.80
KCl 5.80
Resulting hardness in mmol/L: 2.502
Resulting hardness in mg CaCO3/L: 250
Deviations from the nominal weighted loads were less than 5%. Exact values ae recorded in the raw data. After preparation, the dilution water was aerated and the pH was meas-ured. The pH was 7.8. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Species Daphnia magna
Authority STRAUS
Strain Berlin
Sex female
Age between 0 and 24 hours
Origin Umweltbundesamt Berlin
In-house breeding since 27. September 2007
Selection of the test system was made following the proposal of the guidelines.
Daphnia magna is bred in the LAUS GmbH throughout the year. The animals are kept for the use in toxicity tests. They multiply by parthenogenesis, thus being genetically identical. The husbandry is performed similar to the method described in the OECD guideline, following SOP 115 002 01 („Zucht und Hälterung von Daphnia magna STRAUS“), Version 12 from 02. Feb. 2015.
Vessels preserving glasses, nominal volume 2 L
Medium M4-Medium (recipe of ELENDT)
Food unicellular green algae (Desmodesmus subspicatus)
Medium renewal twice a week
Photo period 16/8 hours, using neon tubes
Temperature 20 2 °C - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Post exposure observation period:
- none
- Hardness:
- 250 mg CaCO3 /L
- Test temperature:
- 19.7 - 21.2°C
- pH:
- 7.6-7.7
- Dissolved oxygen:
- 8.5 - 9.1 mg/L
- Salinity:
- not stated
- Conductivity:
- not stated
- Nominal and measured concentrations:
- 100 mg/L nominal, 17.3 mg/L measured (geometric mean)
- Details on test conditions:
- Date of performance 30. Jan. – 01. Feb. 2018
Treatments 100 mg/L
Temperature 19.7 - 21.2°C
Duration 48 hours
Observation times 24 and 48 hours
Medium renewal none
Test vessels glass beakers, nominal volume 50 mL, tall shape
Replicates (Treatments) 4 vessels, each containing 20 ± 5 mL test solution and 5 Daphnia
Replicates (Blank control) 4 vessels, each containing 20 ± 5 mL dilution water and 5 Daphnia - Reference substance (positive control):
- yes
- Key result
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 17.3 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Results with reference substance (positive control):
- Potassium dichromate K2Cr2O7 (CAS No. 7778-50-9) was used as positive control in a current reference study (201701R201). The 24h-EC50 value was determined as 1.6 mg/L. The value was within the requested range for the 24h-EC50 between 0.6 - 2.1 mg/L of po-tassium dichromate K2Cr2O7 as specified in the OECD guideline. Since the fits showed sufficient statistical correspondence of the data with the dose-response-equation, this reference study can be considered valid.
- Reported statistics and error estimates:
- no statistic or error estimates reported
- Validity criteria fulfilled:
- yes
- Conclusions:
- No effect on aquatic invertebrates was noted for Nomcort HK-P under the reported test conditions.
- Executive summary:
One valid experiment was performed.
The study was performed as a limit test using 1 concentration at 100 mg/L (nominal). For each test concentration, 20 Daphnia were exposed to the test item for 48 hours in a static test system. After 24 and 48 hours, the immobilised Daphnia were counted.
After 48h none of the animals was immobilised in the blank control and at 100 mg/L.
Potassium dichromate K2Cr2O7(CAS No. 7778-50-9) was used as positive controlin a current reference study to assure that the test conditions are reliable.
At the start and at the end of the test, the content of the test item in the test solutions was determined using measurement of dissolved organic carbon (DOC). The measured concentration based on TOC measurement was 15% of the nominal concentration at the beginning of the test and 20% of the nominal concentration at the end of the test. Therefore, the determination of the results was based on the geometric mean of the measured concentrations.
The following results were determined for the test itemNomcort HK-P(species:Daphnia magna).Nominal concentration
Geometric mean of measured concentration
48h-NOEC
≥100 mg/L
≥17.3 mg/L
48h-LOEC
> 100 mg/L
> 17.3 mg/L
Reference
Description of key information
One Guideline study available
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
A NOEC of 100 mg/L was found. To perform a chemical safety assessment, this value is used above
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