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EC number: 478-920-0 | CAS number: 457632-32-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 14. Oct. 2016 - 28. Feb. 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: 6-5-A
- Expiration date of the lot/batch: 09. May 2019
- Productiondate: 09.May 2016
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: stored in a tightly closed vessel at room temperature under dry conditions in the dark
- Stability under test conditions: assumed stable
- Solubility and stability of the test substance in the solvent/vehicle: assumed stable and recently soluble
- Reactivity of the test substance with the solvent/vehicle of the cell culture medium: none assumed
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
none - Key result
- Water solubility:
- 16.11 mg/L
- Conc. based on:
- test mat. (dissolved fraction)
- Loading of aqueous phase:
- 101 mg/L
- Incubation duration:
- 3 d
- Temp.:
- 20 °C
- pH:
- 7.3
- Key result
- Water solubility:
- 50.58 mg/L
- Conc. based on:
- test mat. (dissolved fraction)
- Loading of aqueous phase:
- 301 mg/L
- Incubation duration:
- 3 d
- Temp.:
- 20 °C
- pH:
- 7.42
- Key result
- Water solubility:
- 83.67 mg/L
- Conc. based on:
- test mat. (dissolved fraction)
- Loading of aqueous phase:
- 506 mg/L
- Incubation duration:
- 3 d
- Temp.:
- 20 °C
- pH:
- > 6 - < 7
- Key result
- Water solubility:
- 99.06 mg/L
- Conc. based on:
- test mat. (dissolved fraction)
- Loading of aqueous phase:
- 600 mg/L
- Incubation duration:
- 3 d
- Temp.:
- 20 °C
- pH:
- 7.35
- Key result
- Water solubility:
- 132.94 mg/L
- Conc. based on:
- test mat. (dissolved fraction)
- Loading of aqueous phase:
- 804 mg/L
- Incubation duration:
- 3 d
- Temp.:
- 20 °C
- pH:
- 7.32
- Key result
- Water solubility:
- 169.24 mg/L
- Conc. based on:
- test mat. (dissolved fraction)
- Loading of aqueous phase:
- 1 000 mg/L
- Incubation duration:
- 3 d
- Temp.:
- 20 °C
- pH:
- 7.34
- Conclusions:
- The solubility in water of Nomcort HK-P is dependent on the nominal concentration.
In the range of 101 - 1000 mg/L nominal concentration, 16.1 - 169.2 mg/L of Nomcort HK-P were soluble.
Therefore 16.5 % of Nomcort HK-P are water soluble. - Executive summary:
The solubility of the test item Nomcort HK-P in water was determined by measurement of
DOC concentration in the filtrated test solutions using TOC analyser.
In the pre-test, flasks with nominal concentrations 10 mg/L and 1000 mg/L were shaken at
room temperature for three days and measured for DOC after membrane filtration
(0.45 μm and 0.2 μm, PTFE). Undissolved particles were observed in both flasks. Dependency
of solubility on amount of the test item (nominal load) was perceived. According
to the guideline, the flask method was used for the determination of the solubility of the
test item in water.
In the main test, six different loading rates of the test item were chosen to study the effect
of the loading rate on the measured water solubility: 101, 301, 506, 600, 804 and
1000 mg/L (nominal). Three flasks 1A - C with the same loading rate (500 mg/L) were
used during equilibration. Seven vessels (flasks blank, 1C (for the sampling point 72 h)
and 2 – 6) were set onto the shaking apparatus immediately. After 24 ± 2 hours, flask 1B
(for the sampling point 48 h) and after 48 ± 2 hours, flask 1A (for the sampling point 24 h)
were set on the shaker and all flasks were shaken for further 24 ± 2 hours at room temperature
(20.0 ± 0.5 °C). Then, flasks 1A - 1C were taken from the shaker, samples were
taken, membrane filtered and analysed for DOC via TOC analyser. Because of a difference
of less than 15 % in the concentrations on days 2 and 3 and no upward tendency,
the test was finished on day 3.
No Tyndall effect (i.e. a laser beam was not scattered when transmitted through the liquid)
could be observed indicating that no colloidal dispersed particles are present.
Linear dependency of solubility on amount of the test item (nominal load) was perceived in
the main test, too.
Reference
Description of key information
OECD Guideline study available,
additionally, Date from previous Notification is available, however, no information on method or details are given.
Key value for chemical safety assessment
- Water solubility:
- 160 mg/L
- at the temperature of:
- 20 °C
Additional information
Nomcort HK-P is an UVCB substance and only a fraction of 16 % is soluble in water.
The determination was performed in the nominal concentration range of 100 - 1000 mg/L. As key value, the concentration of water soluble fraction at nominal 1000 mg/L is given.
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