Divinylbenzene

Hydrolysis

Link to relevant study record(s)

Reference

Endpoint:

hydrolysis

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Remarks:

experimental data of read across substances

Justification for type of information:

Data for the target chemical is summarized based on the structurally similar read across chemicals

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

WoE report is based on two hydrolysis studies as- 1. and 2.

GLP compliance:

not specified

Specific details on test material used for the study:

- Name of test material (IUPAC Name): 1,2-di(ethenyl)benzene- Common name: Divinyl benzene- Molecular formula: C10H10- Molecular weight: 131.1969 g/mol- Smiles notation: C=Cc1ccccc1C=C- InChI:1S/C10H10/c1-3-9-7-5-6-8-10(9)4-2/h3-8H,1-2H2- Substance type: Organic- Physical state: Liquid

Radiolabelling:

not specified

Analytical monitoring:

not specified

Duration:

30 d

Temp.:

15 °C

Initial conc. measured:

1 mg/L

Remarks:

1) The study was performed at a pH range 4, 7 and 9, respectively.

Duration:

30 d

Temp.:

25 °C

Initial conc. measured:

1 mg/L

Remarks:

1) The study was performed at a pH range 4, 7 and 9, respectively.

Temp.:

55 °C

Remarks:

2) During the study pH ranges from 5-9, respectively.

Number of replicates:

1. Single sample at 15 °C, duplicate samples at 25 °C2. Not specified

Positive controls:

not specified

Negative controls:

not specified

Transformation products:

not specified

pH:

4

Temp.:

15 °C

Remarks on result:

other: No hydrolysis of test chemical was noted.

pH:

7

Temp.:

15 °C

Remarks on result:

other: No hydrolysis of test chemical was noted.

pH:

9

Temp.:

15 °C

DT50:

177 d

Remarks on result:

other: Other details not known

pH:

4

Temp.:

25 °C

DT50:

> 37 - < 50 d

Remarks on result:

other: Other details not known

pH:

7

Temp.:

25 °C

DT50:

> 39 - < 59 d

Remarks on result:

other: Other details not known

pH:

9

Temp.:

25 °C

DT50:

> 49 - < 52 d

Remarks on result:

other: Other details not known

Temp.:

55 °C

DT50:

> 29 - < 146 d

Remarks on result:

other: pH ranges from 5-9, respectively

Details on results:

1. Test chemical was reported to be hydrolytically stable at pH 4, 7 and 9, respectively at a temperature of 15 and 25⁰C. 2. No data available

Validity criteria fulfilled:

not specified

Conclusions:

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical 1,2-di(ethenyl)benzene can be expected to be 37-50, 39-59 and 49-52 days at pH 4, 7 and 9 at 25°C, respectively or ranges from 29 to 146 days at a pH range 5-9 & at a temperature of 55°C, respectively.Thus, based on this half-life value, it can be concluded that the test chemical 1,2-di(ethenyl)benzene is not hydrolysable.

Executive summary:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical 1,2-di(ethenyl)benzene (CAS no. 1321 -74 -0).The studies are as mentioned below:

The half-life of the test chemical was determined at different pH range. The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH). A preliminary test was conducted with fortified samples in pH 4, 7 and 9 buffer solutions over a five–day period at 50 +/- 1°C.The definitive test was conducted with fortified samples in pH 4, 7 and 9 buffer solutions maintained at 15 and 25°C.Samples were subjected to seven sampling intervals over a 30-day period. Samples incubated at 15°C were collected on Day 0. Thereafter samples were collected on Days 2, 3, 10, 25 and 30. Samples incubated at 25°C were collected at Days 0, 2, 3, 10, 17 and 30. Duplicate samples were analyzed at each interval for the 25 degree test, while single samples were analyzed from the 15 degrees C test.Each of the constituents of test chemical were analyzed to determine the test substance concentration in the samples.The half-life value of test chemical at temperature of 15°C was not known, but was reported to be hydrolytically stable at pH 4, 7 and 9, respectively at a temperature of 15 whereas at temperature of 25°C, the half-life value of test chemical was determined to be ranges from 37-50, 39-59 and 49-52 days atpH 4, 7 and 9, respectively.Thus based on this, test chemical is considered to be not hydrolysable.

In an another study, The half-life value of test chemical was determined at a pH range 5-9 and at a temperature of 55°C, respectively. The estimated half-life value of test chemical was determined to be ranges from 29 to 146 days, respectively. Based on the half-life values, it is concluded that the test substance is not hydrolysable.

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical 1,2-di(ethenyl)benzene can be expected to be 37-50, 39-59 and 49-52 days at pH 4, 7 and 9 at 25°C, respectively or ranges from 29 to 146 days at a pH range 5-9 & at a temperature of 55°C, respectively.Thus, based on this half-life value, it can be concluded that the test chemical 1,2-di(ethenyl)benzene is not hydrolysable.

Description of key information

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical 1,2-di(ethenyl)benzene can be expected to be 37-50, 39-59 and 49-52 days at pH 4, 7 and 9 at 25°C, respectively or ranges from 29 to 146 days at a pH range 5-9 & at a temperature of 55°C, respectively. Thus, based on this half-life value, it can be concluded that the test chemical 1,2-di(ethenyl)benzene is not hydrolysable.

Key value for chemical safety assessment

Half-life for hydrolysis:

146 d

Additional information

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical 1,2-di(ethenyl)benzene (CAS no. 1321 -74 -0).The studies are as mentioned below:

 

The half-life of the test chemical was determined at different pH range. The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH). A preliminary test was conducted with fortified samples in pH 4, 7 and 9 buffer solutions over a five–day period at 50 +/- 1°C.The definitive test was conducted with fortified samples in pH 4, 7 and 9 buffer solutions maintained at 15 and 25°C.Samples were subjected to seven sampling intervals over a 30-day period. Samples incubated at 15°C were collected on Day 0. Thereafter samples were collected on Days 2, 3, 10, 25 and 30. Samples incubated at 25°C were collected at Days 0, 2, 3, 10, 17 and 30. Duplicate samples were analyzed at each interval for the 25 degree test, while single samples were analyzed from the 15 degrees C test. Each of the constituents of test chemical were analyzed to determine the test substance concentration in the samples. The half-life value of test chemical at temperature of 15°C was not known, but was reported to be hydrolytically stable at pH 4, 7 and 9, respectively at a temperature of 15 whereas at temperature of 25°C, the half-life value of test chemical was determined to be ranges from 37-50, 39-59 and 49-52 days at pH 4, 7 and 9, respectively. Thus based on this, test chemical is considered to be not hydrolysable.

 

In an another study, The half-life value of test chemical was determined at a pH range 5-9 and at a temperature of 55°C, respectively. The estimated half-life value of test chemical was determined to be ranges from 29 to 146 days, respectively. Based on the half-life values, it is concluded that the test substance is not hydrolysable.

 

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical 1,2-di(ethenyl)benzene can be expected to be 37-50, 39-59 and 49-52 days at pH 4, 7 and 9 at 25°C, respectively or ranges from 29 to 146 days at a pH range 5-9 & at a temperature of 55°C, respectively. Thus, based on this half-life value, it can be concluded that the test chemical 1,2-di(ethenyl)benzene is not hydrolysable.