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Diss Factsheets
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EC number: 239-044-2 | CAS number: 14970-87-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 18 August 2016 (Study Plan dated) to 30 January 2017 (Final Report dated)
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 437 (Bovine Corneal Opacity and Permeability Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage)
- Version / remarks:
- 26 July 2013
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2,2'-[1,2-ethanediylbis(oxy)]bis(ethanethiol)
- EC Number:
- 239-044-2
- EC Name:
- 2,2'-[1,2-ethanediylbis(oxy)]bis(ethanethiol)
- Cas Number:
- 14970-87-7
- Molecular formula:
- C6H14O2S2
- IUPAC Name:
- 2,2'-[1,2-ethanediylbis(oxy)]bis(ethanethiol)
- Test material form:
- liquid
Constituent 1
Test animals / tissue source
- Species:
- other: Bos primigenius taurus
- Details on test animals or tissues and environmental conditions:
- Isolated corneas from the eyes of freshly slaughtered bovine (age of animal: 12-60 months)
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent positive control
- yes, concurrent negative control
- Amount / concentration applied:
- 750 microliter
- Duration of treatment / exposure:
- 10 minutes at 32°C +/- 1°C
- Duration of post- treatment incubation (in vitro):
- 1 hour and 55 minutes at 32°C +/- 1°C
- Number of animals or in vitro replicates:
- 3 fresh bovine corneas
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing
- Time after start of exposure:10 minutes
SCORING SYSTEM: Final opacity value of each cornea
Fluorescein permeability after 85 minutes of incubation at 32 +/- 1°C
TOOL USED TO ASSESS SCORE: opacitometer (opacity), spectrophotometer at 492 nm (permeability)
Results and discussion
In vitro
Results
- Irritation parameter:
- in vitro irritation score
- Value:
- ca. 4.75
- Vehicle controls validity:
- not applicable
- Negative controls validity:
- valid
- Remarks:
- IVIS = 0.12
- Positive controls validity:
- valid
- Remarks:
- IVIS = 82.08
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified eye damage category 1
- Conclusions:
- The test item DMDO induces effects on the cornea, that cannot be classified in an UN GHS Category for eye damage
- Executive summary:
The study was performed to assess corneal damage potential of DMDO by quantitative measurements of changes in opacity and permeability in a bovine cornea. DMDO was brought onto the cornea of a bovine eye which previously had been incubated with cMEM without phenol red at 32 +/- 1°C for 1 hour and whose opacity had been determined. DMDO was incubated on the cornea for 10 minutes at 32 +/- 1°C. After removal of the test item and 1 hour and 55 minutes post-incubation, opacity and permeability values were measured. The negative control (HBSS-solution) and the positive control (undiluted dimethylformamide) have met the validity criteria. No observations were made which might cause doubts concerning the validity of the study outcome. The test is considered valid. DMDO was tested as pure. Under the condition of this test , DMDO showed effects on the cornea of the bovine eye. The calculated IVIS (in vitro irritancy score) is 4.75. According to the OECD Guideline no. 437 (July 2013), a substance with an IVIS >3 and <= 55 induces effects on the cornea, that cannot be classified in an UN GHS Category for eye damage. Nevertheless, the result did not warrant a classifiucation as eye damage category 1.
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