Registration Dossier
Registration Dossier
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EC number: 309-916-8 | CAS number: 101357-19-1
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Qualifier:
- according to guideline
- Guideline:
- other: H.F. Smyth et. aI .: Am. Ind. Hyg. Ass. J. 23, 95-107 (1962)
- GLP compliance:
- no
- Test type:
- fixed concentration procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Similar substance 01
- IUPAC Name:
- Similar substance 01
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- TREATMENT OF TEST MATERIAL PRIOR TO TESTING
For the enrichment 200 L air/h were ducted through a 5 cm layer of the test substance. The mean concentration was calculated to be 6.51 mg/L
FORM AS APPLIED IN THE TEST
solid
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: not specified
- Age at study initiation: not specified
- Weight at study initiation: 547 - 822 g
ENVIRONMENTAL CONDITIONS
not specified
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- not specified
- Vehicle:
- air
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 7 h
- Concentrations:
- calculated concentration: 6.51 mg/L
- No. of animals per sex per dose:
- 6
- Control animals:
- not specified
- Details on study design:
- - Observation period following administration: no
- Frequency of observations: 3, 10, 30 min, 1, 3, 7h
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- 6.51 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 7 h
- Mortality:
- no mortality
- Clinical signs:
- other: no abnormalities
- Body weight:
- not specified
- Gross pathology:
- no results
- Other findings:
- Purple staining of the fur by the test substance was observed throughout the study period.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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