Registration Dossier
Registration Dossier
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EC number: 213-156-1 | CAS number: 927-62-8
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 993
- Reference Type:
- secondary source
- Title:
- 1993. Evaluation of mutagenicity testing with Salmonella typhimurium TA 102 in three different laboratories.
- Author:
- Müller W., Engelhardt G., Herbold B., Jäckh R., Jung R.
- Year:
- 1 993
- Bibliographic source:
- Environ Health Perspect, 101, 33-36; cited in ECETOC JACC, n-butanol, 2003
- Reference Type:
- secondary source
- Title:
- Collaborative study of mutagenicity with Salmonalla typhimurium TA 102.
- Author:
- Jung R., Engelhardt G., Herbolt B., Jäckh R., Müller W.
- Year:
- 1 992
- Bibliographic source:
- Mutat Res, 278, 265-270; cited in ECETOC JACC, n-Butanol, 2003
Materials and methods
- Principles of method if other than guideline:
- Ames test with S. typhimurium TA 102 as described by Maron and Ames (1983) and as specified for TA102 by D. Levin et al . (1982).
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Butan-1-ol
- EC Number:
- 200-751-6
- EC Name:
- Butan-1-ol
- Cas Number:
- 71-36-3
- Molecular formula:
- C4H10O
- IUPAC Name:
- butan-1-ol
- Details on test material:
- - purity: highest purity available
Constituent 1
Method
- Target gene:
- his-
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 102
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9 mix from livers of Aroclor 1254-induced Sprague-Dawley rats
- Test concentrations with justification for top dose:
- up to 5000 µg/plate
- Details on test system and experimental conditions:
- The compounds were tested in at least 2 independent experiments using 5 doses and 3 plates per dose.
Results and discussion
Test results
- Species / strain:
- S. typhimurium TA 102
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- other: up to limit dose or to precipitating or cytotoxic doses
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
