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EC number: 257-446-6 | CAS number: 51818-55-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 2004
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Iron Dichloride
- Author:
- OECD
- Year:
- 2 004
- Bibliographic source:
- SIDS Initial Assessment Report For SIAM 19 (Berlin Germany, 19-22 October 2004)
- Reference Type:
- other: secondary source
- Title:
- Unnamed
- Year:
- 2 004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Iron dichloride
- EC Number:
- 231-843-4
- EC Name:
- Iron dichloride
- Cas Number:
- 7758-94-3
- Molecular formula:
- Cl2Fe
- IUPAC Name:
- iron(2+) dichloride
Constituent 1
- Specific details on test material used for the study:
- - Name of the test material: Iron dichloride
- Purity: 98 %,
- Source and Lot No.: Sigma-Aldrich, Lot No.: 23828CB
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Age of test animals: 8 weeks
- Body weight of test animals during the study: 256.9 – 279.7 g for males and 223.8 – 233.5 g for females
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- corn oil
- Details on dermal exposure:
- - Preparation of test substance: In this study, test article was weighed and wetted with corn oil (CS149, Sigma, Lot No. 122K0131).
- Administration of the test article: Animals were clipped their fur on dorsal part approximately 10 % of the total body surface area one day before dosing. The test article was applied uniformly and held in contact with the skin with a porous gauze dressing and non-irritating tape for 24-hour exposure period. At the end of the exposure period, residual test article was removed using distilled water. - Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not required
- Details on study design:
- - Clinical observations:
Cages of rats were checked at least once a day for any mortality. Animals were individually observed hourly during the first 4 hours after dosing with special attention, and daily for a total of 14 days. The nature and severity of the clinical signs and time were recorded at each observation.
- Body weights:
The body weight of each rat was recorded on day 1 (prior to dosing), day 8 and day 15 (prior to necropsy). Individual body weight changes were calculated.
- Necropsy:
All animals were killed on Day 15 by carbon dioxide asphyxiation and subjected to gross necropsy consisted of opening the thoracic and abnormal cavities. All gross pathological changes were recorded for each animal.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- During the study, there was no unscheduled death.
- Clinical signs:
- other: Yellowish-brown change on the skin of applied site was observed in all treated animals from day 2 but this sign was recorvered on day 15 except 3 animals. 2 males and 4 females showed the reddish nasal discharge on day 2.
- Gross pathology:
- Internally, no abnormalities were observed in all animals by microscopic examination. On application sites, scars were observed in one male and one female.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on the results, the LD50 value was determined to be greater than 2000 mg/kg bw. Thus, the substance does not have to be classified according to CLP regulation 1272/2008.
- Executive summary:
In an acute dermal toxicity study conducted according to OECD guideline 402, groups of Sprague-Dawley rats (5/sex) were treated dermally for 24 hours with 2000 mg/kg bw iron dichloride (98.5% purity). No mortality occurred during the 14-day observation period. Yellowish-brown changes on the skin of applied sites were observed in all treated animals from day 2 but this was recovered during the test period, except for 3 females. 2 males and 4 females showed reddish nasal discharge on day 2. All rats gained normal body weight throughout the study. Regarding gross pathology, no abnormalities were observed in all animals. Only in one male and in one female, scars were observed on the application sites. Based on the results, the dermal LD50 can be considered to be greater than 2000 mg/kg bw.
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