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Diss Factsheets
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EC number: 217-682-2 | CAS number: 1929-82-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 26 January 1962 to 09 February 1962
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Study conducted to sound scientific principles with a sufficient level of detail to assess the quality of the submitted data. The data have been assigned a reliability score of 4 since the study was conducted with a non-standard species.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Remarks:
- Study pre-dates GLP
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Nitrapyrin
- EC Number:
- 217-682-2
- EC Name:
- Nitrapyrin
- Cas Number:
- 1929-82-4
- Molecular formula:
- C6H3Cl4N
- IUPAC Name:
- 2-chloro-6-(trichloromethyl)pyridine
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- Hartley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Fasting period before study: animals were deprived of food for 15 hours prior to test material administration
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- TEST MATERIAL ADMINISTRATION
Animals received a single dose of test material by oral gavage. The test material was delivered using a calibrated syringe and a suitable rubber catheter.
VEHICLE
Test material was administered as a 39.8 % solution in the vehicle. - Doses:
- 252, 500, 1000, 2000, 3980 mg/kg
- No. of animals per sex per dose:
- 5 males per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: animals were weighed before dosing, the following day and at weekly intervals for two weeks thereafter. They were observed periodically for signs of toxicity. Pathological observation is made on representative animals.
- Necropsy of survivors performed: no - Statistics:
- The LD50 was calculated by the Weil modifications of the method of Thompson (Weil, C.S. Biometrics, 8:343, 1952)
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- < 252 other: mg/kg
- Based on:
- test mat.
- Mortality:
- 3 of the 5 animals dosed with 252 or 500 mg/kg test material and all animals dosed with 1000, 2000 or 3980 mg/kg test material died within the first week following test material administration.
- Clinical signs:
- other: No signs of toxicity were noted.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- Under the conditions of the study, the acute oral LD50 of the test material was determined to be less than 252 mg/kg when dosed to male Hartley guinea pigs.
- Executive summary:
The acute oral toxicity of the test material was investigated in a study which was conducted to a method largely relating to that which is outlined in the standardised guideline OECD 401.
During the study, groups of 5 male Hartley guinea pigs received a single dose of test material, by gavage, as a 39.8 % solution in corn oil. Dosage levels were 252, 500, 1000, 2000 and 3980 mg/kg. Animals were weighed before dosing, the following day and weekly thereafter. They were also observed periodically, over the two weeks post-test material administration, for signs of toxicity.
3 of the 5 animals dosed with 252 or 500 mg/kg test material and all animals dosed with 1000, 2000 or 3980 mg/kg test material died within the first week following test material administration. No signs of toxicity were noted.
Under the conditions of the study, the acute oral LD50 of the test material was determined to be less than 252 mg/kg when dosed to male Hartley guinea pigs.
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