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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
23 February 2017 to 20 March 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Key result
Water solubility:
0.004 other: gTOC/L
Conc. based on:
test mat.
Loading of aqueous phase:
0.1 g/L
Incubation duration:
>= 24 - <= 72 h
Temp.:
20 °C
pH:
>= 5.3 - <= 5.5
Details on results:
PRELIMINARY TEST
- The preliminary estimates of water solubility at 20.0 ± 0.5 °C are shown in Table 15 (below)

DEFINITIVE TEST
- Results for total organic carbon analysis are shown in Table 16 (attached).
- Concentration (g/L) of test item in the sample solutions is shown in Table 17 (below).

TABLE 15 – PRELIMINARY ESTIMATES OF WATER SOLUBILITY

Loading rate (g/L)

Concentration (gTOC/L)

pH

0.1

3.36 x 10-3

5.0

1

2.75 x 10-2

4.4

10

0.166

4.3

 

TABLE 17 – CONCENTRATION OF TEST ITEM IN SAMPLE SOLUTIONS

Sample number

Concentration (gTOC/L)

Solution pH

1

4.27 x 10-3

5.4

2

3.93 x 10-3

5.5

3

4.83 x 10-3

5.3

Mean result = 4.34 x 10E-03 gTOC/L at 20.0 ± 0.5 °C

Conclusions:
The water solubility of the test item was determined to be 4.34 x 10E-03 gTOC/L at 20.0 ± 0.5 °C and a nominal loading rate of 0.1 g/L.
Executive summary:

GUIDELINE

The determination was carried by the flask method using a procedure designed to be compatible with Method A.6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.

 

RESULTS

The water solubility of the test item was determined to be 4.34 x 10E-03 gTOC/L at 20.0 ± 0.5 °C and a nominal loading rate of 0.1 g/L.

Description of key information

The water solubility of the test item was determined to be 4.34 x 10E-03 gTOC/L at 20.0 ± 0.5 °C and a nominal loading rate of 0.1 g/L (OECD 105 and EU Method A.6).

Key value for chemical safety assessment

Water solubility:
0.004 g/L
at the temperature of:
20 °C

Additional information

GUIDELINE

The determination was carried by the flask method using a procedure designed to be compatible with Method A.6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.

 

RESULTS

The water solubility of the test item was determined to be 4.34 x 10E-03 gTOC/L at 20.0 ± 0.5 °C and a nominal loading rate of 0.1 g/L.