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EC number: 250-379-3 | CAS number: 30899-62-8
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
No effects up to the limit of water solubility (EU Method C.3), read across.
Key value for chemical safety assessment
Additional information
Since no studies investigating the toxicity of Lauric acid ester with hydroxypropanediyl diacetate (CAS 30899-62-8) to aquatic algae are available, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read-across to the structurally related source substance Glycerides, C8-21 and C8-21-unsatd. mono- and di-, acetates (CAS 97593-30-1) was conducted.
The target substance is mainly characterized as a triester of glycerol esterified with acetic acid and lauric acid. A structurally very similar substance was selected as source substance. Glycerides, C8-21 and C8-21-unsatd. mono- and di-, acetates (CAS 97593-30-1) is a multi-constituent substance described as a triester of glycerol with acetic acid and lauric acid in a slightly different composition compared to the target substance. This read-across is justified in detail in the overall summary (IUCLID Section 6.1) and within the analogue justification in IUCLID Section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was used for the assessment.
The toxicity of the suitable source substance Glycerides, C8-21 and C8-21-unsaturated, mono- and di-, acetates (CAS 97593-30-1) to freshwater algae was conducted according to EU method C.3 (GLP; Weyers, 2007). Desmodesmus subspicatus was exposed to the test substance loading rates of 4.3, 9.4, 21, 45 and 100 mg/L. The actual concentrations of the loading rates were analysed by GC/MS. After the exposure period of 72 h, no effects on algal biomass or growth rate were reported at any of the concentrations tested. Therefore, the EL10/50 (72 h) is > 0.264 mg/L (measured concentration), > 100 mg/L (nominal).
Based on the available result from one structurally related source substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which is characterized by a comparable structure and composition, it can be concluded that Lauric acid ester with hydroxypropanediyl diacetate will not exhibit toxic effects to aquatic algae up to the limit of water solubility.
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