Registration Dossier
Registration Dossier
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EC number: 250-379-3 | CAS number: 30899-62-8
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Readily biodegradable: 83% after 28 d (O2 consumption; OECD 301F); read-across
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
Since no studies investigating the biodegradation of Lauric acid ester with hydroxypropanediyl diacetate (CAS 30899-62-8) are available, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read-across to the structurally related source substance Glycerides, C8-21 and C8-21-unsatd. mono- and di-, acetates (CAS 97593-30-1) was conducted.
The target substance is mainly characterized as a triester of glycerol esterified with acetic acid and lauric acid. A structurally very similar substance was selected as source substance. The source substance Glycerides, C8-21 and C8-21-unsatd. mono- and di-, acetates (CAS 97593-30-1) is a multi-constituent substance described as a triester of glycerol with acetic acid and lauric acid in a slightly different composition compared to the target substance. This read-across is justified in detail in the overall summary (IUCLID Section 6.1) and within the analogue justification in IUCLID Section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was used for the assessment.
The experimental study available for the source substance Glycerides, C8-21 and C8-21-unsaturated, mono- and di-, acetates (CAS 97593-30-1) was conducted according to OECD 301F (GLP; Weyers, 2007). Domestic activated sludge was used as inoculum, being exposed to the test substance at a concentration of 100 mg/L for 28 days at 22 ± 1°C. After 28 days, the test substance reached 83% biodegradation meeting the 10-day window. Thus, the substance is readily biodegradable according to the OECD criteria. This result is confirmed by a reliable QSAR calculation using BIOWIN v4.10. The result indicated that the main components of the substance are readily biodegradable.
Based on the available result from one structurally related source substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which is characterized by a comparable structure, it can be concluded that Lauric acid ester with hydroxypropanediyl diacetate is readily biodegradable.
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