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EC number: 219-524-8 | CAS number: 2454-35-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1999-11-10 to 2000-01-05
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- GLP compliant study based on the Directive 92/69/EEC, C.4-E, 1992, the OECD No. 301 D, 1992 and the EPA Guideline 712-C-98-076: OPPTS 835.3110, 1998
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- Version / remarks:
- (July 17, 1992)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 835.3110 (Ready Biodegradability)
- Version / remarks:
- (January 1998)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-E (Determination of the "Ready" Biodegradability - Closed Bottle Test)
- Version / remarks:
- (December 1992)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- m-acetylphenyl acetate
- EC Number:
- 219-524-8
- EC Name:
- m-acetylphenyl acetate
- Cas Number:
- 2454-35-5
- Molecular formula:
- C10H10O3
- IUPAC Name:
- 3-acetylphenyl acetate
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Purity test date: October 19, 1999
- Lot/batch No.: 489
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: room temperature, light protection
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Final dilution of dissolved solid: 3.04 mg/L test substance (ThOD(NH4) = 6.0 mg O2/L)
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge: domestic sewage treatment plant Groß-Zimmern, Germany
- Preparation of inoculum for exposure: activated sludge was centrifuged, decantated and solid material resuspended in tap water with a final centrifugation
- Pretreatment: suspension with water was aerated until use
- Concentration of sludge: 0.5 mL effluent/L
- Water filtered: no - Duration of test (contact time):
- 28 d
Initial test substance concentrationopen allclose all
- Initial conc.:
- 3.04 mg/L
- Based on:
- test mat.
- Initial conc.:
- 6 mg/L
- Based on:
- ThOD
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Composition of medium: analytical grade salts were added to deionised water to give stock solutions. 1 mL of stock solutions were combined and filled to final volume of 1000 mL with deionised water. The test medium was aerated for 20 minutes and allowed to stand for about 20 hrs at the test temperature. Dissolved oxygen concentration was about 8.7 mg/L at about 20°C.
- Test temperature: 22°C
- pH: 7.5 - 7.6 (measured at the start of the test)
- Aeration of dilution water: yes (see above "composition of medium")
- Continuous darkness: yes
TEST SYSTEM
- Culturing apparatus: Karlsruher flasks of 250 mL volume with glass stopper
- Number of culture flasks/concentration: 16 bottles containing: a) the test substance and inoculum, b) the reference compound Aniline and inoculum (positive control), c) only inoculum (inoculum control). 10 bottles containing test substance, reference compound Aniline and inoculum (toxicity control).
- Method used to create aerobic conditions: inoculum and medium solutions were sufficiently aerated prior to the start of the test.
- Measuring equipment: The oxygen concentrations were electrochemically measured in an airtight system with oxygen-electrode (WTW Oxi 340, Wissenschaftliche Technische Werkstätten GmbH, Weilheim, Germany) under constant stirring.
- Test performed in closed vessels: yes
SAMPLING
- Other: Oxygen measurements were performed in duplicate on days 0, 2, 5, 7, 12, 14, 21 and 28 (measurements of the toxicity control were done only on days 0, 7, 14, 21 and 28).
CONTROL AND BLANK SYSTEM
- Inoculum blank: yes
- Toxicity control: yes
- Other: Inoculum control (only inoculum)
Reference substance
- Reference substance:
- aniline
Results and discussion
% Degradationopen allclose all
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 79
- Sampling time:
- 28 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 72
- Sampling time:
- 10 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 10
- Sampling time:
- 2 d
BOD5 / COD results
- Results with reference substance:
- Degradability of the reference compound Aniline was sufficiently to the mean of 72 % after 14 days, and to 97 % after 28 days of incuation, thus confirming the suitablility of the used activated sludge inoculum.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- Based on a degradation of 79 % (O2 consumption) within 28 d and a degradation of 72 % within 10 d, the substance is readily biodegradable according to OECD criteria.
- Executive summary:
Within the test period of 28 days, a degradation of 79 % was determined for the test substance in an OECD 301D test. Within the test period of 10 days, a degradation of 72 % was determined and the is assumed readily biodegradable.
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