Acetic acid, 2-[(5-chloro-8-quinolinyl)oxy]-

Endpoint summary

Description of key information

Only very slight and transient skin irritation was seen in a rabbit skin irritation study performed with cloquintocet acid: classification for skin irritation is not required. Very slight and transient eye irritation was seen in a rabbit eye irritation study performed with cloquintocet acid: classification for eye irritation is not required.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion

Endpoint conclusion:

no study available

Additional information

Skin Irritation:

An acute dermal irritation study (Verma, 2013a) was conducted according to OECD guideline 404 in three adult male New Zealand White rabbits to assess the potential of the test substance to cause irritation or corrosion to intact skin following a 4 -hour exposure period. The test substance (500 mg) was moistened with 50 mL of distilled water and applied to the treatment skin sites, with a surface of approximately 6 cm². Initially one rabbit was tested. Based on the observations at 24 hour post-patch removal, two additional rabbits were tested simultaneously to confirm the irritation response. The test substance caused a mild and transient local reaction to the treated skin. The mean dermal irritation scores at 24, 48 and 72 hours post-patch removal for individual animals were 0.00, 0.33, 0.33 for erythema and 0.00, 0.00, 0.00 for oedema.

Eye Irritation:

An acute eye irritation study (Verma, 2013b) was conducted according to OECD guideline 405 in three adult female New Zealand White rabbits to assess the potential of the test substance (0.1 mL) to cause irritation or corrosion to the eye. Initially one rabbit was tested. Based on the results obtained at 24 hours post-application, the irritation response was confirmed by testing two additional rabbits simultaneously. The test substance caused a mild eye irritation which resolved by 72 hours post test item application. The individual animal mean eye irritation scores at the 24, 48 and 72 h observation were 0.00, 0.00, 0.00 for corneal opacity, 0.00, 0.00, 0.00 for iris effects, 1.00, 1.00, 1.00 for conjunctival redness and 0.67, 0.00, 0.67 for conjunctival chemosis for rabbit N° 1, 2 and 3, respectively.

In vitro studies are not required due to the availability of in vivo data.

Justification for classification or non-classification

Skin irritation/corrosion:

Cloquintocet acid only caused slight irritation in a skin irritation/corrosion study. Therefore, cloquintocet acid does not therefore require classification as a skin irritant according to the CLP Regulation 1272/2008.

 

Eye irritation/corrosion:

Cloquintocet acid only caused slight irritation in an eye irritation/corrosion study. Therefore, cloquintocet acid does not therefore require classification as an eye irritant according to the CLP Regulation 1272/2008.