Registration Dossier
Registration Dossier
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EC number: 223-531-1 | CAS number: 3943-97-3
Endpoint summary
Administrative data
Description of key information
No data regarding irritation/corrosion (skin, eye or respiratory tract) is available for Methyl p-hydroxycinnamate.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no study available
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
No data is available regarding skin and eye irritation of Methyl p-hydroxycinnamate (4-HCAME). An analogous substance Methyl cinnamate CAS 103-26-4 is not classified for irritation/corrosion based on in vivo test according to OECD 404 and OECD 405 reported in registration dossiers public on ECHA website. Based on no classification provided for the analogous substance Methyl cinnamate CAS 103-26-4 8 in the registration dossier public on ECHA website regarding irritation/corrosion, no classification is proposed for Methyl p-hydroxycinnamate (4-HCAME) regarding skin/eye irritation according to the CLP Regulation (EC n. 1272/2008). This approach is poorly precautionary as the substance has an hydroxyl group that may trigger skin/eye irritation potential. However the classification H317 (Skin sensitisation cat.1) was suggested for these substance (see section 7.4 of IUCLID dossier ) and this alert should be enough to ensure that in any case the workers take the appropriate precautions during the transformation process of the intermediate that it is performed always under strictly controlled conditions. For this reason no classification is proposed for skin, eye or respiratory tract of Methyl p-hydroxycinnamate (4-HCAME) according to the CLP regulation (EC n. 1272/2008). Moreover Methyl p-hydroxycinnamate is a transported isolated intermediate, it is used under strictly controlled conditions so the exposure for worker to Methyl p-hydroxycinnamate is minimized and there is no exposure for general population.
The public ECHA database contains data that are proprietary and cannot be used without the formal consent of the owner. In the present document, some of them have been used for precautionary purposes and for the benefit of the human health and the environment. Those data are not necessary for the registration of the target substance which is used exclusively as isolated and transported intermediate, but they can be very helpful for a better definition of the (eco) toxicological property of the substance. No other use and no commercial advantage will derive from the use of those data.
Justification for classification or non-classification
No data is available regarding skin and eye irritation of Methyl p-hydroxycinnamate (4-HCAME). Based on no classification provided for the analogous substance Methyl cinnamate CAS 103-26-4 8 in the registration dossier public on ECHA website regarding irritation/corrosion, no classification is proposed for Methyl p-hydroxycinnamate (4-HCAME) regarding skin/eye irritation according to the CLP Regulation (EC n. 1272/2008). This approach is poorly precautionary as the substance has an hydroxyl group that may trigger skin/eye irritation potential. However the classification H317 (Skin sensitisation cat.1) was suggested for these substance (see section 7.4 of IUCLID dossier ) and this alert should be enough to ensure that in any case the workers take the appropriate precautions during the transformation process of the intermediate that it is performed always under strictly controlled conditions. For this reason no classification is proposed for skin, eye or respiratory tract of Methyl p-hydroxycinnamate (4-HCAME) according to the CLP regulation (EC n. 1272/2008). Moreover Methyl p-hydroxycinnamate is a transported isolated intermediate, it is used under strictly controlled conditions so the exposure for worker to Methyl p-hydroxycinnamate is minimized and there is no exposure for general population.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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