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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics, other
- Remarks:
- in vitro stability in rat plasma
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26 November 2014 to 22 April 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
- Objective of study:
- other: calculation of half-life in plasma
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- A colormetric method was used to measure the time taken for the boric acid degradation product to neutralise one half of the sodium hydroxide molar equivalent.
- GLP compliance:
- no
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Test material form:
- liquid
- Details on test material:
- - Appearance/physical state: Clear colourless liquid
- Storage conditions: Room temperature in the dark
Results and discussion
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- 2-propyl-1-heptanol
boric acid
Any other information on results incl. tables
ANALYSIS OF ALCOHOL DEGRADATION PRODUCT BY GCMS
- The responses of the hydrolysis product (2-propyl-1-heptanol) in Experiment 1 are shown in Table 1 (attached).
- The results of Experiment 2 are shown in Table 2 (attached).
ANALYSIS OF BORIC ACID NEUTRALISATION OF SODIUM HYDROXIDE
- The results of Experiments 1 and 2 are shown in Table 3 (below).
TABLE 3 – TIME TAKEN FOR BORIC ACID NEUTRALISATION
Nominal concentration (mM) |
Nomination concentration sodium hydroxide (mM) |
Experiment 1 (seconds) |
Experiment 2 (seconds) |
Mean half-life (seconds) |
0.6 |
0.3 |
65 |
67 |
66 |
Applicant's summary and conclusion
- Conclusions:
- The mean half-life of the test item hydrolysis was 66 seconds. No definitive data was obtained that enabled half-life data to be measured for the alcohol degradation product by GCMS, however, based on the data obtained it can be positively concluded that some hydrolysis has occurred almost immediately and potentially reaches a hydrolysis maximum within approximately 1 hour.
- Executive summary:
METHODS
The purpose of the study was to develop methods that would enable the in vitro stability of the test item in rat plasma to be measured and where possible calculate a half-life value for the test item. The test item was known to rapidly degrade in water to boric acid and 2-propyl-1-heptanol. Two approaches were taken, analysis of the formation of the alcohol degradation product by GCMS and a colormetric indicator method. This measured the time taken for one half the amount of sodium hydroxide molar equivalent necessary to neutralize the boric acid resulting from complete hydrolysis of the ester.
RESULTS
The mean half-life of the test item hydrolysis was determined to be 66 seconds. No definitive data was obtained that enabled half-life data to be measured for the alcohol degradation product by GCMS, however, based on the data obtained it can be positively concluded that some hydrolysis has occurred almost immediately and potentially reaches a hydrolysis maximum within approximately 1 hour.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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